HoxC12 Antibody (LX-O): sc-81966

HoxC12 Antibody (LX-O) is a mouse monoclonal IgG2a kappa light chain antibody that detects HoxC12 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HoxC12 antibody (LX-O) is available as a non-conjugated format. HoxC12, also known as Homeobox C12, is a crucial transcription factor that plays a significant role in gene expression regulation during embryonic development and cellular differentiation. HoxC12 is involved in axial patterning, essential for proper formation of body structures along the anterior-posterior axis. HoxC12 belongs to the larger family of Hox proteins, which interact with various downstream target genes to orchestrate complex developmental processes. HoxC12 is encoded by a gene located within the HoxC cluster and consists of 282 amino acids, featuring a homeobox DNA-binding domain that enables specific DNA sequence binding and gene transcription regulation. Precise regulation of HoxC12 is vital, as dysregulation can lead to developmental disorders and contribute to leukemia pathogenesis. Through critical DNA-protein interactions, HoxC12 serves as a key player in the intricate network of transcriptional regulation necessary for normal development and cellular function.

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HoxC12 Antibody (LX-O) References:

1. Complete mutation analysis panel of the 39 human HOX genes.  |  Kosaki, K., et al. 2002. Teratology. 65: 50-62. PMID: 11857506
2. Hoxc12 expression pattern in developing and cycling murine hair follicles.  |  Shang, L., et al. 2002. Mech Dev. 113: 207-10. PMID: 11960714
3. Vertebrate homeobox gene nomenclature.  |  Scott, MP. 1992. Cell. 71: 551-3. PMID: 1358459
4. The spatial restrictions of 5'HoxC genes expression are maintained in adult newt spinal cord.  |  Nicolas, S., et al. 2003. Biol Cell. 95: 589-94. PMID: 14720461
5. Nomenclature for human homeobox genes.  |  McAlpine, PJ. and Shows, TB. 1990. Genomics. 7: 460. PMID: 1973146
6. The human HOX gene family.  |  Acampora, D., et al. 1989. Nucleic Acids Res. 17: 10385-402. PMID: 2574852
7. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.  |  Flagiello, D., et al. 1997. FEBS Lett. 415: 263-7. PMID: 9357979

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HoxC12 Antibody (LX-O) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HoxC12 Antibody (LX-O) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HoxC12 Antibody (LX-O) Specifications

Alternate Product Name: HoxC12

Product Clone Name: LX-O

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-101

Epitope Target: HoxC12

Epitope Species: human

Product Reactivity/Detection: HoxC12

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HoxC12 Antibody (LX-O): N/A