HoxB7 Antibody (747C4a): sc-81292
- HoxB7 Antibody (747C4a) is a mouse monoclonal IgG1 HoxB7 antibody, cited in 7 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to the N-terminal region of HoxB7 of human origin
- recommended for detection of HoxB7 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HoxB7 Antibody (747C4a). This work is in progress.
HoxB7 Antibody (747C4a) is a mouse monoclonal IgG1 antibody that detects HoxB7 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-HoxB7 antibody (747C4a) is available as a non-conjugated format. HoxB7 protein is crucial for proper embryonic development and cellular differentiation, as HoxB7 regulates the expression of downstream target genes essential for establishing the anterior-posterior body axis. Located within the mammalian HOX gene complex, which comprises 39 genes spread across four chromosomes, HoxB7 plays a significant role in directing DNA-protein and protein-protein interactions that shape morphologic features during development. A segment of the HoxB7 proximal promoter is responsible for renal expression, specifically in the ureteric bud and collecting ducts, highlighting HoxB7′s importance in kidney development. Studies have shown that HoxB7 expression levels are significantly lower in lymph node metastasis-positive cancer tissues compared to negative ones, suggesting that dysregulation of HOX genes, including HoxB7, may contribute to the progression of breast cancer and aggressive behavior of cancer cells.
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HoxB7 Antibody (747C4a) References:
- Role of PLZF in melanoma progression. | Felicetti, F., et al. 2004. Oncogene. 23: 4567-76. PMID: 15077196
- Real-time analysis of ureteric bud branching morphogenesis in vitro. | Watanabe, T. and Costantini, F. 2004. Dev Biol. 271: 98-108. PMID: 15196953
- Overexpression of RET leads to vesicoureteric reflux in mice. | Yu, OH., et al. 2004. Am J Physiol Renal Physiol. 287: F1123-30. PMID: 15328070
- TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. | Oxburgh, L., et al. 2004. Development. 131: 4593-605. PMID: 15342483
- Identification of two candidate collecting duct cell-specific cis-acting elements in the Hoxb-7 promoter region. | Plaisier, E., et al. 2005. Biochim Biophys Acta. 1727: 106-15. PMID: 15716052
- Aberrant expression of HOX genes in human invasive breast carcinoma. | Makiyama, K., et al. 2005. Oncol Rep. 13: 673-9. PMID: 15756441
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HoxB7 Antibody (747C4a) | sc-81292 | 100 µg/ml | $333.00 |