HoxA5 Antibody (129C1a): sc-81289

HoxA5 Antibody (129C1a) is a mouse monoclonal IgG2a antibody that detects HoxA5 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). HoxA5 is a crucial transcriptional regulator that plays a significant role in the expression of multiple target genes, including the tumor suppressor p53 and the progesterone receptor, making HoxA5 vital for cellular responses to DNA damage, particularly in breast cancer cells. HoxA5′s importance extends beyond regulatory functions; HoxA5 is dynamically expressed during critical developmental processes such as gut development and organogenesis of the respiratory tract. Notably, HoxA5 is continuously expressed from the neonatal period into adulthood in cerebellar Purkinje cells, highlighting HoxA5′s role in maintaining neuronal function. Furthermore, HoxA5 is essential for the region-specific differentiation of the endoderm and the myeloid lineage, as well as for the correct specification of the cervical and upper thoracic regions of the skeleton, which is crucial for proper embryonic patterning. Loss of HoxA5 expression has been linked to tumorigenesis, particularly in primary breast carcinomas, where HoxA5 correlates with the loss of p53 expression, underscoring HoxA5′s importance in cancer biology.

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HoxA5 Antibody (129C1a) References:

1. HOXA5 counteracts the function of pathological scar-derived fibroblasts by partially activating p53 signaling.  |  Liang, Y., et al. 2021. Cell Death Dis. 12: 40. PMID: 33414417
2. HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression.  |  Zhang, Y., et al. 2021. Circulation. 144: 638-654. PMID: 34098726
3. HOXA5 induces M2 macrophage polarization to attenuate carotid atherosclerosis by activating MED1.  |  Jing, Y., et al. 2021. IUBMB Life. 73: 1142-1152. PMID: 34117711
4. HOXA5 is amplified in glioblastoma stem cells and promotes tumor progression by transcriptionally activating PTPRZ1.  |  He, ZC., et al. 2022. Cancer Lett. 533: 215605. PMID: 35219772
5. Expression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma.  |  Gao, L., et al. 2022. Int J Med Sci. 19: 572-587. PMID: 35370463
6. HOXA5-Mediated Stabilization of IκBα Inhibits the NF-κB Pathway and Suppresses Malignant Transformation of Breast Epithelial Cells.  |  Pai, P., et al. 2022. Cancer Res. 82: 3802-3814. PMID: 36166646
7. HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway.  |  Xiong, F., et al. 2022. Cell Death Dis. 13: 829. PMID: 36167790
8. HOXA5: A crucial transcriptional factor in cancer and a potential therapeutic target.  |  Fan, F., et al. 2022. Biomed Pharmacother. 155: 113800. PMID: 36271576
9. CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug.  |  Liang, Y., et al. 2022. Mol Cancer. 21: 224. PMID: 36536414
10. The Transcription Factor HOXA5: Novel Insights into Metabolic Diseases and Adipose Tissue Dysfunction.  |  Parrillo, L., et al. 2023. Cells. 12: PMID: 37626900
11. TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signaling.  |  Ye, J., et al. 2023. Cell Death Discov. 9: 378. PMID: 37845209
12. Hypermethylation leads to the loss of HOXA5, resulting in JAG1 expression and NOTCH signaling contributing to kidney fibrosis.  |  Xiao, X., et al. 2024. Kidney Int. 106: 98-114. PMID: 38521405

The preferred HoxA5 antibody is HoxA5 Antibody (C-11): sc-365784.