HoxA4 Antibody (H-4): sc-515418

HoxA4 Antibody (H-4) is a mouse monoclonal IgM antibody that detects HoxA4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HoxA4 antibody (H-4) is available as the non-conjugated form. HoxA4, also known as homeobox A4, is a crucial transcriptional regulator consisting of 320 amino acids and is primarily located in the nucleus, where HoxA4 contains a homeobox DNA-binding domain. HoxA4 is essential for embryonic development, particularly in nervous system formation, acting as a sequence-specific DNA-binding transcription factor that helps establish positional identities in developing cells. HoxA4′s ability to bind to specific DNA sequences is vital for regulating gene expression, morphogenesis, and differentiation, processes fundamental to proper embryonic development. HoxA4 is situated on human chromosome 7, a region harboring over 1,000 genes and accounting for nearly 5% of the human genome. Mutations or defects in genes on this chromosome have been associated with various developmental disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome, highlighting HoxA4′s importance in maintaining normal developmental pathways.

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HoxA4 Antibody (H-4) References:

1. Complete mutation analysis panel of the 39 human HOX genes.  |  Kosaki, K., et al. 2002. Teratology. 65: 50-62. PMID: 11857506
2. Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL.  |  Strathdee, G., et al. 2006. Leukemia. 20: 1326-9. PMID: 16688227
3. Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells.  |  Buettner, R., et al. 1991. Mol Cell Biol. 11: 3573-83. PMID: 1675427
4. Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias.  |  Chen, T., et al. 2007. Eur J Hum Genet. 15: 23-8. PMID: 17003840
5. Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia.  |  Grubach, L., et al. 2008. Eur J Haematol. 81: 112-22. PMID: 18410541
6. Expression of HOX homeogenes in human neuroblastoma cell culture lines.  |  Peverali, FA., et al. 1990. Differentiation. 45: 61-9. PMID: 1981366
7. Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox.  |  Ferguson-Smith, AC., et al. 1989. Genomics. 5: 250-8. PMID: 2571574
8. Organization of human class I homeobox genes.  |  Boncinelli, E., et al. 1989. Genome. 31: 745-56. PMID: 2576652
9. HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.  |  Stelnicki, EJ., et al. 1998. J Invest Dermatol. 110: 110-5. PMID: 9457903

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HoxA4 Antibody (H-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-HoxA4 Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HoxA4 Antibody (H-4) Specifications

Alternate Product Name: HoxA4

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 65-84

Epitope Target: HoxA4

Epitope Species: mouse

Product Reactivity/Detection: HoxA4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for HoxA4 Antibody (H-4): P: Blocking Peptide, X: TransCruz Reagent