Hordenine (CAS 539-15-1)
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Hordenine has antibacterial and antibiotic properties. When the the affects of Hordenine on melanogenesis and its mechanisms of action in epidermal melanocytes was studied, Hordenine was found to significantly inhibit Melanin content. It was also found to reduce the intracellular cAMP levels, as well as, inhibit the expression of microphthalmia-associated transcription factor (MITF). When the quorum sensing (QS)-mediated pathogenicity of Horedenine was studied, Hordenin was used to downregulate the expressions of QS- and biofilm-related genes in the tomato- S. marcescens host-pathogen system. Hordenine is released from barley malt during mashing and has recently been identified as a functionally selective dopamine D2 receptor (D2DR) agonist. Related products include Hordenine Sulfate Dihydrate (sc-295161).
Hordenine (CAS 539-15-1) References
- Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse. | Frank, M., et al. 1990. Equine Vet J. 22: 437-41. PMID: 2269269
- Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes. | Kim, SC., et al. 2013. Food Chem. 141: 174-81. PMID: 23768344
- Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat. | Barwell, CJ., et al. 1989. J Pharm Pharmacol. 41: 421-3. PMID: 2570842
- Hordenine: A Novel Quorum Sensing Inhibitor and Antibiofilm Agent against Pseudomonas aeruginosa. | Zhou, JW., et al. 2018. J Agric Food Chem. 66: 1620-1628. PMID: 29353476
- Monitoring of the dopamine D2 receptor agonists hordenine and N-methyltyramine during the brewing process and in commercial beer samples. | Sommer, T., et al. 2019. Food Chem. 276: 745-753. PMID: 30409657
- Inhibition of Quorum Sensing and Virulence in Serratia marcescens by Hordenine. | Zhou, JW., et al. 2019. J Agric Food Chem. 67: 784-795. PMID: 30609368
- Metabolomic analysis of quorum sensing inhibitor hordenine on Pseudomonas aeruginosa. | Zhou, JW., et al. 2019. Appl Microbiol Biotechnol. 103: 6271-6285. PMID: 31161392
- Antiprolactinoma Effect of Hordenine by Inhibiting MAPK Signaling Pathway Activation in Rats. | Wang, X., et al. 2020. Evid Based Complement Alternat Med. 2020: 3107290. PMID: 32382283
- Hordenine Protects Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation. | Zhang, X., et al. 2021. Front Pharmacol. 12: 712232. PMID: 34539399
- Quantification of hordenine in a complex plant matrix by direct analysis in real time-high-resolution mass spectrometry: Application to the 'plant of concern' Sceletium tortuosum. | Appley, MG., et al. 2022. Drug Test Anal. 14: 604-612. PMID: 34750996
- Hordenine inhibits neuroinflammation and exerts neuroprotective effects via inhibiting NF-κB and MAPK signaling pathways in vivo and in vitro. | Su, Y., et al. 2022. Int Immunopharmacol. 108: 108694. PMID: 35349959
- Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro. | Hahn, M., et al. 2022. PLoS One. 17: e0269486. PMID: 35709159
- Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway. | Wang, C., et al. 2023. Nutrients. 15: PMID: 36771401
- Beneficial Effects of Hordenine on a Model of Ulcerative Colitis. | Xu, Z., et al. 2023. Molecules. 28: PMID: 36985809
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hordenine, 100 mg | sc-279195 | 100 mg | $77.00 | |||
Hordenine, 1 g | sc-279195A | 1 g | $561.00 |