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Hopantenate Calcium (CAS 17097-76-6)

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Alternate Names:
Calcium D-(+)-Homopantothenate
CAS Number:
17097-76-6
Molecular Weight:
504.59
Molecular Formula:
C20H36CaN2O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hopantenate Calcium plays a role in cellular metabolism by participating in the synthesis of coenzyme A, an essential molecule involved in various metabolic pathways. It interacts with enzymes such as pantothenate kinase and phosphopantothenoylcysteine synthetase, facilitating the conversion of pantothenate into coenzyme A. This process is vital for the production of energy, the metabolism of fats, carbohydrates, and proteins, and the synthesis of important cellular components such as fatty acids and cholesterol. Hopantenate Calcium′s mechanism of action involves its incorporation into the structure of coenzyme A, allowing it to participate in enzymatic reactions that drive cellular processes and pathways. Its presence is for the proper functioning of cellular metabolism and the maintenance of cellular health.


Hopantenate Calcium (CAS 17097-76-6) References

  1. Acute encephalopathy with hepatic steatosis induced by pantothenic acid antagonist, calcium hopantenate, in dogs.  |  Noda, S., et al. 1991. Liver. 11: 134-42. PMID: 1886458
  2. Lactic acidosis with hypoglycemia and hyperammonemia observed in two uremic patients during calcium hopantenate treatment.  |  Otsuka, M., et al. 1990. Jpn J Med. 29: 324-8. PMID: 2273615
  3. Urinary organic acids in elderly Japanese patients with ketosis and encephalopathy who have taken panto-yl-gamma-aminobutyrate, calcium salt (calcium hopantenate, HOPA).  |  Nakanishi, T., et al. 1990. Clin Chim Acta. 188: 85-90. PMID: 2347085
  4. Effects of the anti-dementia drug hopantenate calcium upon striatal dopaminergic neurons in young and aged rats.  |  Toide, K. 1989. Arch Int Pharmacodyn Ther. 299: 7-13. PMID: 2570556
  5. Clinical and biochemical effects of calcium-hopantenate on neuroleptics-induced tardive dyskinesia.  |  Kashihara, K., et al. 1985. Folia Psychiatr Neurol Jpn. 39: 147-53. PMID: 2866149
  6. Hopantenic acid beta-glucoside as a new urinary metabolite of calcium hopantenate in dogs.  |  Nakano, K., et al. 1986. Drug Metab Dispos. 14: 740-5. PMID: 2877836
  7. Calcium hopantenate, a GABA agonist, induces elevation of plasma beta-endorphin-like immunoreactivity levels in rats.  |  Mitsuma, T., et al. 1987. Exp Clin Endocrinol. 89: 181-7. PMID: 2956119
  8. Effects of calcium hopantenate on neurotransmitter receptors in the rat brain.  |  Ogawa, N., et al. 1985. Jpn J Pharmacol. 37: 45-50. PMID: 2985852
  9. Effects of calcium hopantenate on the release of thyrotropin-releasing hormone from the rat adrenal gland in vitro.  |  Mitsuma, T., et al. 1987. Horm Metab Res. 19: 475-7. PMID: 3123349
  10. A possible mechanism on the potentiating vascular effect of coadministration of ifenprodil tartrate and calcium hopantenate: a study in the internal carotid artery.  |  Shibuya, T., et al. 1988. Int J Clin Pharmacol Ther Toxicol. 26: 448-52. PMID: 3198300
  11. A possible mechanism on the potentiated vascular effect of coadministration of ifenprodil tartrate and calcium hopantenate: a study in the basilar and vertebral arteries.  |  Shibuya, T., et al. 1988. Int J Clin Pharmacol Ther Toxicol. 26: 534-9. PMID: 3243656
  12. Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.  |  Noda, S., et al. 1988. J Neurol Neurosurg Psychiatry. 51: 582-5. PMID: 3379435
  13. Acute encephalopathy with hyperammonemia and dicarboxylic aciduria during calcium hopantenate therapy: a patient report.  |  Kimura, A., et al. 1986. Brain Dev. 8: 601-5. PMID: 3826551
  14. Effects of calcium hopantenate on the hypothalamic-pituitary-thyroid axis in rats.  |  Mitsuma, T. and Nogimori, T. 1983. Horm Res. 18: 210-4. PMID: 6416983

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hopantenate Calcium, 1 mg

sc-490634
1 mg
$393.00