Molecular structure of Homovanillic acid, CAS Number: 306-08-1
Homovanillic acid (CAS 306-08-1)
Alternate Names:
HVA; 4-Hydroxy-3-methoxyphenylacetic acid
Application:
Homovanillic acid is Fluorimetric reagent and major catecholamine metabolite
CAS Number:
306-08-1
Purity:
≥98%
Molecular Weight:
182.17
Molecular Formula:
C9H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Homovanillic acid is a fluorimetric reagent and major catecholamine metabolite. Homovanillic acid is used for fluorimetric determination of oxidative enzymes including glucose oxidase. Homovanillic acid (HVA) is a significant organic compound that serves as a major metabolite of the neurotransmitter dopamine. Derived from vanillic acid, Homovanillic acid is produced in the body during dopamine metabolism. This compound plays a pivotal role as a biomarker in the investigation of neuropsychiatric disorders, enabling the measurement of dopamine concentrations in the brain.
Homovanillic acid (CAS 306-08-1) References
- Difficulties in establishing reference intervals for special fluids: the example of 5-hydroxyindoleacetic acid and homovanillic acid in cerebrospinal fluid. | Dhondt, JL. 2004. Clin Chem Lab Med. 42: 833-41. PMID: 15327020
- Homovanillic acid measurement in clinical research: a review of methodology. | Amin, F., et al. 1992. Schizophr Bull. 18: 123-48. PMID: 1553492
- Quantitation of homovanillic acid (HVA) and vanillylmandelic acid (VMA) in urine using gas chromatography-mass spectrometry (GC/MS). | Allenbrand, R. and Garg, U. 2010. Methods Mol Biol. 603: 261-9. PMID: 20077077
- A novel l-leucine modified Sol-Gel-Carbon electrode for simultaneous electrochemical detection of homovanillic acid, dopamine and uric acid in neuroblastoma diagnosis. | Khamlichi, RE., et al. 2017. Mater Sci Eng C Mater Biol Appl. 71: 870-878. PMID: 27987784
- Quantification of vanillylmandelic acid, homovanillic acid and 5-hydroxyindoleacetic acid in urine using a dilute-and-shoot and ultra-high pressure liquid chromatography tandem mass spectrometry method. | Grouzmann, E., et al. 2018. Clin Chem Lab Med. 56: 1533-1541. PMID: 29708876
- Differential pulse voltammetric determination of homovanillic acid as a tumor biomarker in human urine after hollow fiber-based liquid-phase microextraction. | Hrdlička, V., et al. 2021. Talanta. 221: 121594. PMID: 33076128
- Plasma homovanillic acid as a predictor of response to neuroleptics. | Davila, R., et al. 1988. Arch Gen Psychiatry. 45: 564-7. PMID: 3377643
- A Simple, Fast, and Reliable LC-MS/MS Method for the Measurement of Homovanillic Acid and Vanillylmandelic Acid in Urine Specimens. | Pandya, V. and Frank, EL. 2022. Methods Mol Biol. 2546: 175-183. PMID: 36127588
- Quantitation of Neuroblastoma Markers Homovanillic Acid (HVA) and Vanillylmandelic Acid (VMA) in Urine by Gas Chromatography-Mass Spectrometry (GC/MS). | Beals, M., et al. 2022. Methods Mol Biol. 2546: 185-194. PMID: 36127589
- Voltammetric Detection of Vanillylmandelic Acid and Homovanillic Acid Using Urea-Derivative-Modified Graphite Electrode. | Shishkanova, TV., et al. 2023. Sensors (Basel). 23: PMID: 37050787
- Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates. | Elsworth, JD., et al. 1987. J Neural Transm. 68: 51-62. PMID: 3806086
- Determination of urinary vanilmandelic acid and homovanillic acid by high performance liquid chromatography with amperometric detection. | Bauersfeld, W., et al. 1982. J Clin Chem Clin Biochem. 20: 217-20. PMID: 7077238
- Serum homovanillic acid levels in schizophrenic patients and normal control subjects. | Steinberg, JL., et al. 1993. Psychiatry Res. 48: 93-106. PMID: 8416025
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Homovanillic acid, 50 mg | sc-204002 | 50 mg | $20.00 | |||
Homovanillic acid, 100 mg | sc-204002A | 100 mg | $23.00 | |||
Homovanillic acid, 1 g | sc-204002B | 1 g | $57.00 |