Molecular structure of Homoquinolinic acid, CAS Number: 490-75-5
Homoquinolinic acid (CAS 490-75-5)
Application:
Homoquinolinic acid is a NMDA receptor agonist and potent neurotoxic agent
CAS Number:
490-75-5
Purity:
>99%
Molecular Weight:
181.15
Molecular Formula:
C8H7NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Homoquinolinic acid, a rigid analog of glutamic acid, may act to be a potent excitant of rat cortical neurons and a potent neurotoxic agent. Mechanistic studies suggest that this compound causes excitation by acting on NMDA (N-methyl-D-aspartate) receptors. Further studies report that Homoquinolinic acid may specifically target the NR2A/B subunit of NMDA receptors. Homoquinolinic acid is an activator of NMDA.
Homoquinolinic acid (CAS 490-75-5) References
- NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. | Woodhall, G., et al. 2001. J Neurophysiol. 86: 1644-51. PMID: 11600627
- Ethanol differentially inhibits homoquinolinic acid- and NMDA-induced neurotoxicity in primary cultures of cerebellar granule cells. | Cebere, A. and Liljequist, S. 2003. Neurochem Res. 28: 1193-9. PMID: 12834259
- Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. | Martin, G., et al. 2004. J Pharmacol Exp Ther. 311: 265-73. PMID: 15263066
- Background synaptic activity in rat entorhinal cortical neurones: differential control of transmitter release by presynaptic receptors. | Jones, RS. and Woodhall, GL. 2005. J Physiol. 562: 107-20. PMID: 15498804
- Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors. | Mameli, M., et al. 2005. J Neurosci. 25: 2285-94. PMID: 15745954
- Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission. | Mameli, M., et al. 2005. J Neurosci. 25: 8027-36. PMID: 16135760
- Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission. | Madara, JC. and Levine, ES. 2008. J Neurophysiol. 100: 3175-84. PMID: 18922945
- Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes. | Olverman, HJ., et al. 1988. Neuroscience. 26: 17-31. PMID: 2901691
- Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors. | Wang, JX., et al. 2020. Nat Commun. 11: 423. PMID: 31969570
- Excitant activity of methyl derivatives of quinolinic acid on rat cortical neurones. | Stone, TW. 1984. Br J Pharmacol. 81: 175-81. PMID: 6546701
- Dextromethorphan and other N-methyl-D-aspartate receptor antagonists are teratogenic in the avian embryo model. | Andaloro, VJ., et al. 1998. Pediatr Res. 43: 1-7. PMID: 9432105
- [3H]homoquinolinate binds to a subpopulation of NMDA receptors and to a novel binding site. | Brown, JC., et al. 1998. J Neurochem. 71: 1464-70. PMID: 9751179
Activator of:
NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Homoquinolinic acid, 5 mg | sc-200456 | 5 mg | $117.00 | |||
Homoquinolinic acid, 25 mg | sc-200456A | 25 mg | $587.00 |