Homoquinolinic acid, a rigid analog of glutamic acid, has been shown to be a potent excitant of rat cortical neurons and a potent neurotoxic agent. Mechanistic studies suggest that this compound causes excitation by acting on NMDA (N-methyl-D-aspartate) receptors. Further studies report that Homoquinolinic acid may specifically target the NR2A/B subunit of NMDA receptors. Homoquinolinic acid is an activator of NMDA.
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