Homoquinolinic acid CAS: 490-75-5
MF: C8H7NO4
MW: 181.15
A NMDA receptor agonist and potent neurotoxic agent.

Homoquinolinic acid (CAS 490-75-5)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 107ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: Homoquinolinic acid is a NMDA receptor agonist and potent neurotoxic agent
CAS Number: 490-75-5
Purity: >99%
Molecular Weight: 181.15
Molecular Formula: C8H7NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Homoquinolinic acid, a rigid analog of glutamic acid, has been shown to be a potent excitant of rat cortical neurons and a potent neurotoxic agent. Mechanistic studies suggest that this compound causes excitation by acting on NMDA (N-methyl-D-aspartate) receptors. Further studies report that Homoquinolinic acid may specifically target the NR2A/B subunit of NMDA receptors. Homoquinolinic acid is an activator of NMDA.


References

1. Stone, T.W. 1984. Br. J. Pharmacol. 81: 175-181. PMID: 6546701
2. Woodhall, G., et al. 2001. J. Neurophysiol. 86: 1644-1651. PMID: 11600627
3. Cebere, A., et al. 2003. Neurochem. Res. 28: 1193-1199. PMID: 12834259

Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH (100 mM).
Storage :
Store at room temperature
Melting Point :
148.85° C (Predicted)
Boiling Point :
437.02° C at 760 mmHg (Predicted)
Density :
1.48 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Glutamate NMDA receptor: IC50 = 10 µM (rat)
pK Values :
pKa: 0.98, pKb: 5.04
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3080554
MDL Number :
MFCD00214066
SMILES :
C1=CC(=C(N=C1)C(=O)O)CC(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 100ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.