Homo Sildenafil-d5: sc-280778
Homo Sildenafil-d5
Alternate Names:
5-[2-Ethoxy-5-[(4-(ethyl-d5)-1-piperazinyl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin -7-one
Application:
Homo Sildenafil-d5 is a deuterium-labelled analog of Sildenafil and potential PDE5 inhibitor
Molecular Weight:
493.63
Molecular Formula:
C23H27D5N6O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Homo Sildenafil-d5 is a deuterium-labelled analog of Sildenafil (sc-338584). Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3′,5′-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.
Homo Sildenafil-d5 References
- Chinese proprietary medicine in Singapore: regulatory control of toxic heavy metals and undeclared drugs. | Koh, HL. and Woo, SO. 2000. Drug Saf. 23: 351-62. PMID: 11085343
- Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles. | Seftel, AD. 2004. Clin Cardiol. 27: I14-19. PMID: 15115191
- The role of sildenafil in the treatment of stroke. | Bednar, MM. 2008. Curr Opin Investig Drugs. 9: 754-9. PMID: 18600581
- Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism. | Kato, N., et al. 2009. Dig Dis Sci. 54: 2346-56. PMID: 19101800
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Homo Sildenafil-d5, 1 mg | sc-280778 | 1 mg | $360.00 |