Molecular structure of Homo Sildenafil, CAS Number: 642928-07-2
Homo Sildenafil (CAS 642928-07-2)
Application:
Homo Sildenafil is A new analog of sildenafil
CAS Number:
642928-07-2
Molecular Weight:
488.60
Molecular Formula:
C23H32N6O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Homo Sildenafil is a new analog of Sildenafil (sc-338584). Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.
Homo Sildenafil (CAS 642928-07-2) References
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- The role of sildenafil in the treatment of stroke. | Bednar, MM. 2008. Curr Opin Investig Drugs. 9: 754-9. PMID: 18600581
- Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism. | Kato, N., et al. 2009. Dig Dis Sci. 54: 2346-56. PMID: 19101800
- Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks. | Venhuis, BJ. and de Kaste, D. 2012. J Pharm Biomed Anal. 69: 196-208. PMID: 22464558
- Clinical evaluation of drug-drug interactions between the cytochrome P450 substrates selexipag and clopidogrel in Japanese volunteers. | Katayama, N., et al. 2021. Br J Clin Pharmacol. 87: 1903-1911. PMID: 32997809
- A concise review of bioanalytical methods of small molecule immuno-oncology drugs in cancer therapy. | Sulochana, SP., et al. 2021. Biomed Chromatogr. 35: e4996. PMID: 33047346
- Rapid screening of illegal additives in functional food using atmospheric pressure solids analysis probe coupled to a portable mass spectrometer. | Wang, X., et al. 2022. J Pharm Biomed Anal. 214: 114722. PMID: 35325799
- A multi-analyte screening method for the rapid detection of illicit adulterants in dietary supplements using a portable SERS analyzer. | Rizzo, S., et al. 2023. Heliyon. 9: e18509. PMID: 37520973
Inhibitor of:
PDE5A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Homo Sildenafil, 2.5 mg | sc-211595 | 2.5 mg | $380.00 |