holo-Transferrin (CAS 11096-37-0)
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Holo-Transferrin is a key component in cellular biology research, particularly in studies related to iron homeostasis and metabolism. This protein is the iron-bound form of transferrin and is utilized to understand how cells uptake iron, a critical process for cell proliferation and growth. In cell culture systems, holo-Transferrin is used to supplement media, providing a physiologically relevant source of iron to cells in vitro. It is also instrumental in studies investigating the regulation of iron-responsive genes and proteins, as it interacts directly with transferrin receptors on the cell surface. Researchers use holo-Transferrin to trace the intracellular pathway of iron, from internalization to its release in the cytoplasm, which has implications for understanding iron-related disorders. Furthermore, the compound is involved in the study of the immune system′s response to pathogens, as iron availability can influence the outcome of microbial infections.
holo-Transferrin (CAS 11096-37-0) References
- Iron-dependent binding of bovine milk α-casein with holo-lactoferrin, but not holo-transferrin. | Shibuya, N., et al. 2012. Biometals. 25: 1083-8. PMID: 22824971
- Influence of platelet γ-glutamyltransferase on oxidative stress and apoptosis in the presence of holo-transferrin. | Sener, A., et al. 2012. Folia Biol (Praha). 58: 193-202. PMID: 23249638
- Metallomics for drug development: an integrated CE-ICP-MS and ICP-MS approach reveals the speciation changes for an investigational ruthenium(III) drug bound to holo-transferrin in simulated cancer cytosol. | Aleksenko, SS., et al. 2013. Metallomics. 5: 955-63. PMID: 23799586
- Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers. | Hersom, M., et al. 2016. Mol Cell Neurosci. 76: 59-67. PMID: 27567687
- Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma. | Zhu, M., et al. 2017. ACS Appl Mater Interfaces. 9: 39249-39258. PMID: 29039909
- Iron transport kinetics through blood-brain barrier endothelial cells. | Khan, AI., et al. 2018. Biochim Biophys Acta Gen Subj. 1862: 1168-1179. PMID: 29466707
- Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load. | Fillebeen, C., et al. 2019. Blood. 133: 344-355. PMID: 30538134
- Oil-in-water nanoemulsions comprising Berberine in olive oil: biological activities, binding mechanisms to human serum albumin or holo-transferrin and QMMD simulations. | Sharifi-Rad, A., et al. 2021. J Biomol Struct Dyn. 39: 1029-1043. PMID: 32000592
- Iron elevates mesenchymal and metastatic biomarkers in HepG2 cells. | Mehta, KJ. and Sharp, PA. 2020. Sci Rep. 10: 21926. PMID: 33318518
- Intracellular Iron Binding and Antioxidant Activity of Phytochelators. | Silva, FT. and Espósito, BP. 2022. Biol Trace Elem Res. 200: 3910-3918. PMID: 34648123
- Extraintestinal pathogenic Escherichia coli utilizes the surface-expressed elongation factor Tu to bind and acquire iron from holo-transferrin. | Sun, Y., et al. 2022. Virulence. 13: 698-713. PMID: 35443872
- Extraintestinal Pathogenic Escherichia coli Utilizes Surface-Located Elongation Factor G to Acquire Iron from Holo-Transferrin. | Sun, Y., et al. 2022. Microbiol Spectr. 10: e0166221. PMID: 35477220
- Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein. | Baringer, SL., et al. 2022. Fluids Barriers CNS. 19: 49. PMID: 35689283
- Functional role of endothelial transferrin receptor 1 in iron sensing and homeostasis. | Fisher, AL., et al. 2022. Am J Hematol. 97: 1548-1559. PMID: 36069607
- Novel O-Methylglucoside Derivatives of Flavanone in Interaction with Model Membrane and Transferrin. | Cyboran-Mikołajczyk, S., et al. 2022. Membranes (Basel). 12: PMID: 36295737
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
holo-Transferrin, 100 mg | sc-391098 | 100 mg | $120.00 | |||
holo-Transferrin, 500 mg | sc-391098A | 500 mg | $325.00 |