Molecular structure of Hoechst 34580, CAS Number: 911004-45-0
Hoechst 34580 (CAS 911004-45-0)
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Alternate Names:
N,N-Dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5′-bi-1H-benzimidazol]-2′-yl]benzenamine trihydrochloride; HOE 34580
Application:
Hoechst 34580 is Hoechst 34580 is a suitable fluorogenic substrate for esterases/lipases
CAS Number:
911004-45-0
Molecular Weight:
560.95
Molecular Formula:
C27H29N7•3HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hoechst 34580 is a suitable fluorogenic substrate for esterases/lipases. The synthesis of Hoechst 34580 involves a multi-step process. It starts with the condensation of 4-nitro-N,N-dimethylaniline and 2,5-dimethoxybenzaldehyde to create a Schiff base. This compound is then reduced to yield the corresponding amine. Next, the amine is reacted with 2,5-diaminobenzoic acid to produce the desired benzimidazole derivative. This derivative is further reacted with 4-methylpiperazine to ultimately form the final product. The resulting product is purified and transformed into its trihydrochloride salt form.Hoechst 34580 is a valuable compound for research purposes. Its chemical formula is C27H32Cl3N7, with a molecular weight of 560.95 g/mol, and it typically exhibits a purity level of around 95%.
Hoechst 34580 (CAS 911004-45-0) References
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- Host-guest interaction of Hoechst 34580 and Cucurbit[7]uril. | Lei, W., et al. 2011. Chemphyschem. 12: 2933-40. PMID: 21919182
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- Assessment of liposome disruption to quantify drug delivery in vitro. | Nogueira, E., et al. 2016. Biochim Biophys Acta. 1858: 163-7. PMID: 26589183
- Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. | Thai, NQ., et al. 2016. J Comput Aided Mol Des. 30: 639-50. PMID: 27511370
- A fluorescence in situ staining method for investigating spores and vegetative cells of Clostridia by confocal laser scanning microscopy and structured illuminated microscopy. | D'Incecco, P., et al. 2018. Micron. 110: 1-9. PMID: 29689432
- Application of fluorescence lifetime imaging microscopy of DNA binding dyes to assess radiation-induced chromatin compaction changes. | Abdollahi, E., et al. 2018. Int J Mol Sci. 19: PMID: 30110966
- Development of a highly sensitive, quantitative, and rapid detection system for Plasmodium falciparum-infected red blood cells using a fluorescent blue-ray optical system. | Yamamoto, T., et al. 2019. Biosens Bioelectron. 132: 375-381. PMID: 30901727
- Behavioral disturbances induced by cyanobacterial oligopeptides microginin-FR1, anabaenopeptin-A and microcystin-LR are associated with neuromotoric and cytotoxic changes in Brachionus calyciflorus. | Bownik, A., et al. 2022. J Hazard Mater. 438: 129472. PMID: 35785735
Substrate of:
Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hoechst 34580, 5 mg | sc-396575 | 5 mg | $105.00 | |||
Hoechst 34580, 50 mg | sc-396575A | 50 mg | $500.00 |