HNMPA-(AM)3 (CAS 120944-03-8)
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HNMPA-(AM)3 is a cell-permeable analog of HNMPA that, once inside cells, is converted into its original form by esterase action. This compound acts as an inhibitor of the insulin receptor tyrosine kinase, effectively hindering the autophosphorylation process of the human insulin receptor on tyrosine residues. Additionally, it serves as a small molecule inhibitor aimed at the N-methyl-D-aspartate (NMDA) receptor, which is in the study of neurodegenerative conditions. By blocking the activation of this receptor, HNMPA-(AM)3 helps in reducing the harmful effects associated with excessive glutamate levels, such as excitotoxicity and oxidative stress, factors known to contribute to neurodegenerative diseases. Furthermore, it plays a role in neuronal differentiation and cognitive function by binding to its specific receptor, thereby controlling the influx of calcium ions into cells, which, if unregulated, can lead to cell damage.
HNMPA-(AM)3 (CAS 120944-03-8) References
- Possible mode of action for insulinomimetic activity of vanadyl(IV) compounds in adipocytes. | Kawabe, K., et al. 2006. Life Sci. 78: 2860-6. PMID: 16337244
- The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma. | Rose, PP., et al. 2007. Oncogene. 26: 1995-2005. PMID: 17001305
- PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca(2+)/calmodulin and receptor tyrosine kinase. | Gu, SH., et al. 2010. J Insect Physiol. 56: 93-101. PMID: 19800889
- Insulin stabilizes microvascular endothelial barrier function via phosphatidylinositol 3-kinase/Akt-mediated Rac1 activation. | Gündüz, D., et al. 2010. Arterioscler Thromb Vasc Biol. 30: 1237-45. PMID: 20339116
- AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia. | Leclerc, GM., et al. 2010. J Mol Signal. 5: 15. PMID: 20863384
- Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix. | Juan, YC., et al. 2011. J Ethnopharmacol. 137: 592-600. PMID: 21704145
- Delta cell secretory responses to insulin secretagogues are not mediated indirectly by insulin. | Hauge-Evans, AC., et al. 2012. Diabetologia. 55: 1995-2004. PMID: 22526610
- Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola. | Cazarolli, LH., et al. 2012. Fitoterapia. 83: 1176-83. PMID: 22796400
- Involvement of GLUT-4 in the stimulatory effect of rutin on glucose uptake in rat soleus muscle. | Kappel, VD., et al. 2013. J Pharm Pharmacol. 65: 1179-86. PMID: 23837585
- Inhibition of Rab5 Activation During Insulin Receptor-Mediated Endocytosis. | Jozic, I., et al. 2011. Curr Cell Biochem. 1: 20-32. PMID: 24765621
- Adaptive potentiation in rod photoreceptors after light exposure. | McKeown, AS. and Kraft, TW. 2014. J Gen Physiol. 143: 733-43. PMID: 24821966
- The Zinc Transporter Zip7 Is Downregulated in Skeletal Muscle of Insulin-Resistant Cells and in Mice Fed a High-Fat Diet. | Norouzi, S., et al. 2019. Cells. 8: PMID: 31266232
- LGI1 governs neuritin-mediated resilience to chronic stress. | Lee, SH., et al. 2021. Neurobiol Stress. 15: 100373. PMID: 34401409
- Coexpression network analysis coupled with connectivity map database mining reveals novel genetic biomarkers and potential therapeutic drugs for polymyositis. | Wang, K., et al. 2022. Clin Rheumatol. 41: 1719-1730. PMID: 35091780
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HNMPA-(AM)3, 5 mg | sc-221730 | 5 mg | $186.00 |