Molecular structure of HNHA, CAS Number: 926908-04-5
HNHA (CAS 926908-04-5)
Alternate Names:
Histone Deacetylase Inhibitor VI
Application:
HNHA is an HDAC (histone deacetylase) inhibitor
CAS Number:
926908-04-5
Molecular Weight:
303.4
Molecular Formula:
C17H21NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
HNHA is a cell-permeable inhibitor of HDAC (histone deacetylase) activity (IC50 = 100 nM). HNHA induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC50 ~ 7.5 μM) in human fibrosarcoma HT1080 cells. Another function of HNHA is blocking retinal neovascularization and choroidal angiogenesis in mice. HNHA also inhibits the growth of human umbilical vein endothelial cells (HUVECs) and prevents tube formation and migration of HUVECs in response to vascular endothelial growth factor (VEGF).
HNHA (CAS 926908-04-5) References
1 Kim, D.H., Lee, J., Kim, K.N., et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor. Biochem Biophys Res Commun 356 233-238 (2007). 2 Kim, J.H., Kim, J.H., Oh, M., et al. N-hydroxy-7-(2-naphthylthio) heptanomide inhibits retinal and choroidal angiogenesis. Molecular Pharmaceutics 6(2) 513-519 (2009).Inhibitor of:
HDAC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HNHA, 5 mg | sc-205343 | 5 mg | $161.00 | |||
HNHA, 10 mg | sc-205343A | 10 mg | $405.00 |