Molecular structure of HMBA
HMBA
Application:
HMBA is an inhibitor of microtubule polymerization that interacts with tubulin
Molecular Weight:
328.36
Molecular Formula:
C22H16O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
An inhibitor of microtubule polymerization. An apoptosis inducer.
HMBA References
- HMBA inhibits growth and induces differentiation of astrocytes from neonatal rat brain. | Shirsat, NV. 1999. Neuroreport. 10: 3755-8. PMID: 10716204
- Growth inhibition and differentiation of C6 glioma cells on treatment with hmba. | Shirsat, NV., et al. 2001. Cell Biol Int. 25: 621-7. PMID: 11448101
- New designed HMBA agents as inducers of erythroleukemia cell differentiation. | Wang, H., et al. 2002. Chin Med Sci J. 17: 27-31. PMID: 12894881
- Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells. | Choudhary, SK., et al. 2008. J Infect Dis. 197: 1162-70. PMID: 18419522
- 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. | Prinz, H., et al. 2009. J Med Chem. 52: 1284-94. PMID: 19220018
- HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen. | Lama, R., et al. 2017. J Steroid Biochem Mol Biol. 168: 91-101. PMID: 28213333
- BET bromodomain inhibitor HMBA synergizes with MEK inhibition in treatment of malignant glioma. | Funck-Brentano, E., et al. 2021. Epigenetics. 16: 54-63. PMID: 32603264
- Induction of transformed cells to terminal differentiation. | Marks, PA., et al. 1987. Ann N Y Acad Sci. 511: 246-55. PMID: 3326466
- Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. | Richon, VM., et al. 1996. Proc Natl Acad Sci U S A. 93: 5705-8. PMID: 8650156
- Further investigation of some inhibitors on myogenic differentiation: mechanism of inhibition with HMBA on quail myoblasts transformed with Rous sarcoma virus. | Hase, H., et al. 1996. Cell Struct Funct. 21: 17-25. PMID: 8726470
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HMBA, 10 mg | sc-300799 | 10 mg | $59.00 |