HMBA AM resin
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HMBA AM resin is an intriguing material utilized extensively in the field of chemistry, particularly for solid-phase synthesis applications. The "HMBA" in the name stands for 4-hydroxymethylbenzoic acid, a compound that is used as a linker in the resin, allowing the attachment of other molecules. The "AM" refers to the amide functional group, which is a part of the resin structure and plays a role in its reactivity. This resin is essentially a polystyrene-based material that has been functionalized with the HMBA linker. The polystyrene forms a solid and robust matrix, while the HMBA linker extends from this matrix and can form covalent bonds with a variety of other compounds. The presence of the amide (AM) functional group enhances the stability and versatility of the resin, making it suitable for a wide range of applications. The HMBA AM resin beads are typically swollen in an appropriate solvent, such as dichloromethane or dimethylformamide, prior to use. This swelling allows the resin to interact more effectively with other chemicals in a reaction mixture.
HMBA AM resin References
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- Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria. | Emtenäs, H., et al. 2002. J Comb Chem. 4: 630-9. PMID: 12425608
- Role of electrostatic interactions in PDZ domain ligand recognition. | Harris, BZ., et al. 2003. Biochemistry. 42: 2797-805. PMID: 12627945
- Hetaryleneaminopolyols and hetarylenecarbopeptoids: a new type of glyco- and peptidomimetics. Syntheses and studies on solution conformation and dynamics. | Moreno-Vargas, AJ., et al. 2003. J Org Chem. 68: 4138-50. PMID: 12762712
- Improved solution- and solid-phase preparation of hydroxamic acids from esters. | Ho, CY., et al. 2005. J Org Chem. 70: 4873-5. PMID: 15932334
- Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. | Nören-Müller, A., et al. 2006. Proc Natl Acad Sci U S A. 103: 10606-11. PMID: 16809424
- N-linked glycosylated beta-peptides are resistant to degradation by glycoamidase A. | Disney, MD., et al. 2005. Chem Biodivers. 2: 1624-34. PMID: 17191959
- Synthesis of new, base-modified PNA monomers. | Sipos, F. and Sági, G. 2007. Nucleosides Nucleotides Nucleic Acids. 26: 681-5. PMID: 18066879
- Lipopentapeptide induces a strong host humoral response and distinguishes Mycobacterium avium subsp. paratuberculosis from M. avium subsp. avium. | Biet, F., et al. 2008. Vaccine. 26: 257-68. PMID: 18068277
- Convenient Synthesis of a Library of Discrete Hydroxamic Acids Using the Hydroxythiophenol (Marshall) Resin. | Choi, J., et al. 2008. Tetrahedron Lett. 49: 1103-1106. PMID: 18443652
- Solid phase synthesis of a functionalized bis-peptide using 'safety catch' methodology. | Pfeiffer, CT. and Schafmeister, CE. 2012. J Vis Exp. e4112. PMID: 22635107
- A spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell culture. | Brown, ZZ., et al. 2012. PLoS One. 7: e45948. PMID: 23094022
- Modulating the Cellular Uptake of Fluorescently Tagged Substrates of Prostate-Specific Antigen before and after Enzymatic Activation. | Di Marco, L., et al. 2019. Bioconjug Chem. 30: 124-133. PMID: 30566337
- Development and characterisation of SMURF2-targeting modifiers. | Manikoth Ayyathan, D., et al. 2021. J Enzyme Inhib Med Chem. 36: 401-409. PMID: 33430646
- Engineering Synthetic Lipopeptide Antigen for Specific Detection of Mycobacterium avium subsp. paratuberculosis Infection. | Bay, S., et al. 2021. Front Vet Sci. 8: 637841. PMID: 33969035
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HMBA AM resin, 1 g | sc-473598 | 1 g | $46.00 |