HLI 373 (CAS 502137-98-6)
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HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription. Additionally induces apoptosis in several tumor cell lines (LOX-IMVI, A549 and HT1080) expressing wild-type p53. HLI 373 is a substance that hinders the activity of Hdm2 ubiquitin ligase (E3), which is responsible for promoting the breakdown of p53 through a process called ubiquitylation, followed by degradation in the proteasome. By inhibiting Hdm2, HLI 373 prevents the ubiquitylation and subsequent degradation of p53, leading to the activation of p53-dependent transcription. As a result, HLI 373 induces apoptosis (cell death) specifically in various tumor cell lines that possess the wild-type p53 gene.
HLI 373 (CAS 502137-98-6) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLI 373, 10 mg | sc-358833 | 10 mg | $173.00 | |||
| US: Only available in the US | ||||||
HLI 373, 50 mg | sc-358833A | 50 mg | $712.00 | |||
| US: Only available in the US | ||||||