HLA-E Antibody (MEM-E/06): sc-51622
- HLA-E Antibody (MEM-E/06) is a mouse monoclonal IgG1, cited in 3 publications, provided at 100 µg/ml
- raised against bacterially expressed recombinant human HLA-E refolded with β2-microglubulin and peptide
- recommended for detection of native surface-expressed HLA-E of human origin by WB, IP, IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-E Antibody (MEM-E/06). This work is in progress.
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HLA-E Antibody (MEM-E/06) is a mouse monoclonal IgG1 antibody that detects HLA-E in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). HLA-E plays a crucial role in the immune system by presenting a limited set of peptides derived from the leader sequences of other major histocompatibility complex (MHC) class I molecules, which is essential for the regulation of immune responses. This unique function allows HLA-E to interact with inhibitory receptors on natural killer (NK) cells, thereby contributing to the maintenance of immune tolerance and preventing autoimmunity. HLA-E′s ability to bind these specific peptides is vital for modulating the activity of immune cells, ensuring that the body can effectively respond to infections while avoiding damage to its own tissues. Anti-HLA-E antibody (MEM-E/06) is an invaluable tool for researchers studying immune regulation and the intricate mechanisms of antigen presentation, providing insights into both normal immune function and pathological conditions.
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HLA-E Antibody (MEM-E/06) References:
- Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions. | Morandi, F. and Pistoia, V. 2014. Front Immunol. 5: 394. PMID: 25202308
- HLA-E: exploiting pathogen-host interactions for vaccine development. | Sharpe, HR., et al. 2019. Clin Exp Immunol. 196: 167-177. PMID: 30968409
- HLA-E-restricted, Gag-specific CD8+ T cells can suppress HIV-1 infection, offering vaccine opportunities. | Yang, H., et al. 2021. Sci Immunol. 6: PMID: 33766848
- Thermal-exchange HLA-E multimers reveal specificity in HLA-E and NKG2A/CD94 complex interactions. | Ruibal, P., et al. 2023. Immunology. 168: 526-537. PMID: 36217755
- MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis. | Kim, SJ. and Karamooz, E. 2022. Int J Mol Sci. 23: PMID: 36430890
- The complex HLA-E-nonapeptide in Behçet disease. | Castaño-Núñez, ÁL., et al. 2023. Front Immunol. 14: 1080047. PMID: 37638008
- Non-classical HLA-E restricted CMV 15-mer peptides are recognized by adaptive NK cells and induce memory responses. | Martín Almazán, N., et al. 2023. Front Immunol. 14: 1230718. PMID: 37809084
- Immune checkpoints HLA-E:CD94-NKG2A and HLA-C:KIR2DL1 complementarily shield circulating tumor cells from NK-mediated immune surveillance. | Liu, X., et al. 2024. Cell Discov. 10: 16. PMID: 38336855
- An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis. | Paterson, RL., et al. 2024. Proc Natl Acad Sci U S A. 121: e2318003121. PMID: 38691588
- Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor. | Sætersmoen, M., et al. 2025. Med. 6: 100521. PMID: 39423821
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-E Antibody (MEM-E/06) | sc-51622 | 100 µg/ml | $322.00 |