HLA-DQ1/3 Antibody (HL-37): sc-51615
- HLA-DQ1/3 Antibody (HL-37) is a mouse monoclonal IgG3 HLA-DQ1/3 antibody provided at 100 µg/ml
- raised against Burkitt's lymphoma cell line Raji of human origin
- recommended for detection of polymorphic determinant on HLA-DQ1 and HLA-DQ3 of human origin by WB (non-reducing), IP and FCM
- available conjugated to phycoerythrin for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-DQ1/3 Antibody (HL-37). This work is in progress.
HLA-DQ1/3 Antibody (HL-37) is a mouse monoclonal IgG3 antibody that detects the HLA-DQ1/3 protein of human origin by western blotting (WB) (non-reducing), immunoprecipitation (IP), and flow cytometry (FCM). Anti-HLA-DQ1/3 antibody (HL-37) is available as a non-conjugated format. HLA-DQ1/3 plays a crucial role in the immune system as a major histocompatibility complex (MHC) class II molecule, which is essential for presenting peptide antigens to CD4+ T lymphocytes. This process is vital for initiating and regulating immune responses, particularly in the context of autoimmune diseases and transplant rejection. HLA-DQ1/3 consists of a 33-35 kDa alpha chain and a 26-28 kDa beta chain, forming a heterodimer that can effectively bind and present a diverse array of peptides. HLA-DQ1/3′s ability to present specific antigens is influenced by conformational changes, modulated by interactions with other proteins such as HLA-DM and HLA-DO, ensuring that only the most relevant peptides are presented to T cells. Understanding HLA-DQ1/3′s structure and function is critical for developing targeted therapies in conditions like rheumatoid arthritis, where specific polymorphisms in HLA genes have been linked to disease susceptibility.
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HLA-DQ1/3 Antibody (HL-37) References:
- HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus. | Siegmund, T., et al. 1999. Tissue Antigens. 54: 291-4. PMID: 10519369
- The association of HLA-DM genes with rheumatoid arthritis in Eastern France. | Toussirot, E., et al. 2000. Hum Immunol. 61: 303-8. PMID: 10689120
- Functional characterization of a lysosomal sorting motif in the cytoplasmic tail of HLA-DObeta. | Brunet, A., et al. 2000. J Biol Chem. 275: 37062-71. PMID: 10964920
- The down-regulation of HLA-DM gene expression in rheumatoid arthritis is not related to their promoter polymorphism. | Louis-Plence, P., et al. 2000. J Immunol. 165: 4861-9. PMID: 11046010
- Determination of the HLA-DM interaction site on HLA-DR molecules. | Doebele, RC., et al. 2000. Immunity. 13: 517-27. PMID: 11070170
- Characterization of seven new monoclonal antibodies against human DR, DR + DP and DQ1 + DQ3 antigens. | Horejsí, V., et al. 1986. Tissue Antigens. 28: 288-97. PMID: 2435017
- B-cell lymphomas of high-grade malignancy frequently lack HLA-DR, -DP and -DQ antigens and associated invariant chain. | Momburg, F., et al. 1987. Int J Cancer. 40: 598-603. PMID: 3316049
- Human Ia molecules carrying DC1 determinants differ in both alpha- and beta-subunits from Ia molecules carrying DR determinants. | Corte, G., et al. 1981. Nature. 292: 357-60. PMID: 6166865
- A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules. | Kropshofer, H., et al. 1998. EMBO J. 17: 2971-81. PMID: 9606180
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DQ1/3 Antibody (HL-37) | sc-51615 | 100 µg/ml | $316.00 |