HLA-DQ Antibody (HLADQ1): sc-73390
- HLA-DQ Antibody (HLADQ1) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against peripheral blood mononuclear cells of human origin
- recommended for detection of HLA-DQ of human origin by IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-DQ Antibody (HLADQ1). This work is in progress.
HLA-DQ Antibody (HLADQ1) is a mouse monoclonal IgG1 antibody that detects HLA-DQ in human samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). HLA-DQ is a crucial component of the major histocompatibility complex (MHC) class II molecules, which play a vital role in the immune response by presenting processed antigens to CD4+ T lymphocytes. The structure of HLA-DQ consists of two polypeptide chains, alpha and beta, that form a heterodimer capable of binding a diverse array of peptide antigens. This structural configuration facilitates the recognition of a wide variety of foreign peptides and ensures effective immune system responses to numerous pathogens. The ability of HLA-DQ to present antigens is essential for T cell activation, which orchestrates adaptive immune responses. Variations in HLA-DQ structure can influence susceptibility to autoimmune diseases, making anti-HLA-DQ antibody (HLADQ1) an invaluable tool for studying antigen presentation dynamics and HLA-DQ′s role in various immunological contexts.
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HLA-DQ Antibody (HLADQ1) References:
- The Relationship of HLA-DQ Alleles with Tuberculosis Risk: A Meta-analysis. | Li, C., et al. 2015. Lung. 193: 521-30. PMID: 26007157
- HLA-DQ Mismatches and Rejection in Kidney Transplant Recipients. | Lim, WH., et al. 2016. Clin J Am Soc Nephrol. 11: 875-883. PMID: 27034399
- HLA-DQ β1 alleles associated with Epstein-Barr virus (EBV) infectivity and EBV gp42 binding to cells. | Li, Q., et al. 2017. JCI Insight. 2: e85687. PMID: 28239644
- Anti-HLA-DQ antibodies are highly and independently related to the C1q-binding capacity of HLA antibodies. | Arreola-Guerra, JM., et al. 2017. Transpl Immunol. 41: 10-16. PMID: 28284929
- HLA-DQ: Celiac disease vs inflammatory bowel disease. | Bosca-Watts, MM., et al. 2018. World J Gastroenterol. 24: 96-103. PMID: 29358886
- HLA-DQ Typing Kits in Diagnosis and Screening for Celiac Disease. | Rouvroye, MD., et al. 2019. Genet Test Mol Biomarkers. 23: 418-422. PMID: 31066583
- HLA-DQ alloantibodies directly activate the endothelium and compromise differentiation of FoxP3high regulatory T lymphocytes. | Cross, AR., et al. 2019. Kidney Int. 96: 689-698. PMID: 31307777
- Assessment of HLA-A, HLA-DR, and HLA-DQ alleles in patients with pemphigus vulgaris from eastern of Turkey. | Dere, G., et al. 2020. J Cosmet Dermatol. 19: 2432-2437. PMID: 31944522
- HLA-DQ mismatches stimulate de novo donor specific antibodies in heart transplant recipients. | Zhang, X., et al. 2020. Hum Immunol. 81: 330-336. PMID: 32307126
- HLA-DQ and alcohol in the pathogenesis of irritable bowel syndrome in college students: a case-control study. | Liu, H., et al. 2023. Sci Rep. 13: 13023. PMID: 37563425
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DQ Antibody (HLADQ1) | sc-73390 | 100 µg/ml | $316.00 |