HLA-DP/DR/DQ Antibody (7.5.10.1): sc-59238

HLA-DP/DR/DQ Antibody (7.5.10.1) is a mouse monoclonal IgG2a kappa light chain antibody designed to target the HLA-DR, HLA-DP, and HLA-DQ proteins, which are collectively known as Major Histocompatibility Complex class II (MHC II) molecules. These proteins are primarily located on the surface of antigen-presenting cells such as B lymphocytes, dendritic cells, and macrophages, where they play a crucial role in the immune system by presenting processed antigenic peptides to CD4+ helper T cells. This antigen presentation is essential for initiating and regulating adaptive immune responses, making MHC II molecules vital for effective immune surveillance and maintenance of immune tolerance. Anti-HLA-DP/DR/DQ antibody (7.5.10.1) is raised against human lymphocytes, demonstrating specificity for both human and canine HLA-DR, HLA-DP, and HLA-DQ proteins. HLA-DP/DR/DQ (7.5.10.1) antibody is recommended for use in immunofluorescence (IF) applications, providing reliable detection in various experimental settings. Understanding and targeting these MHC class II molecules is important in research areas such as autoimmune diseases, transplantation, and immunotherapy, where modulation of immune responses is critical. By utilizing HLA-DP/DR/DQ monoclonal antibody (7.5.10.1), researchers can effectively study the expression and function of these proteins, contributing to advancements in immunological studies and therapeutic strategy development. The broad reactivity of HLA-DP/DR/DQ (7.5.10.1) antibody across human and canine species makes this antibody a versatile tool for comparative studies and translational research, enhancing utility in diverse scientific investigations.

The preferred HLA-DR antibody is HLA-DR Antibody (L243): sc-18875.