HLA-DP β1 Antibody (7-RE35): sc-134357

HLA-DP β1 Antibody (7-RE35) is a mouse monoclonal IgG2a kappa light chain antibody that detects the HLA-DP beta 1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-HLA-DP beta 1 antibody (7-RE35) is available as the non-conjugated monoclonal isotype antibody. HLA-DP beta 1 (7-RE35) monoclonal antibody recognizes a protein that plays a crucial role in the immune response as a component of the major histocompatibility complex (MHC) class II molecules, which are essential for presenting processed antigens to CD4+ T helper cells. This interaction is vital for the activation of the adaptive immune system, allowing for a targeted response to pathogens. HLA-DP beta 1 is primarily located on the surface of antigen-presenting cells, such as B cells and dendritic cells, where HLA-DP beta 1 forms a heterodimer with the alpha chain of HLA-DP. This localization enables efficient presentation of extracellular antigens, which are internalized, processed, and then displayed on the cell surface for recognition by T cells. Proper functioning of HLA-DP beta 1 is critical for immune surveillance and maintenance of immune tolerance, and any dysfunction in this pathway can lead to autoimmune diseases or impaired immune responses.

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HLA-DP β1 Antibody (7-RE35) References:

1. HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus.  |  Siegmund, T., et al. 1999. Tissue Antigens. 54: 291-4. PMID: 10519369
2. The association of HLA-DM genes with rheumatoid arthritis in Eastern France.  |  Toussirot, E., et al. 2000. Hum Immunol. 61: 303-8. PMID: 10689120
3. Functional HLA-DM on the surface of B cells and immature dendritic cells.  |  Arndt, SO., et al. 2000. EMBO J. 19: 1241-51. PMID: 10716924
4. Functional characterization of a lysosomal sorting motif in the cytoplasmic tail of HLA-DObeta.  |  Brunet, A., et al. 2000. J Biol Chem. 275: 37062-71. PMID: 10964920
5. The down-regulation of HLA-DM gene expression in rheumatoid arthritis is not related to their promoter polymorphism.  |  Louis-Plence, P., et al. 2000. J Immunol. 165: 4861-9. PMID: 11046010
6. Determination of the HLA-DM interaction site on HLA-DR molecules.  |  Doebele, RC., et al. 2000. Immunity. 13: 517-27. PMID: 11070170
7. Differential splenic migration of dendritic cells after immunologic unresponsiveness in rat hepatic allografts induced by pretransplant donor-specific transfusion.  |  Ohshiro, H., et al. 2001. J Surg Res. 101: 29-36. PMID: 11676551
8. Monoclonal antibodies to HLA-DP-transfected mouse L cells.  |  Heyes, J., et al. 1986. Proc Natl Acad Sci U S A. 83: 3417-21. PMID: 3517859
9. Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation.  |  Ruggeri, A., et al. 2023. Haematologica. 108: 645-652. PMID: 35546480
10. Next-generation HLA sequencing reveals the novel HLA-DPB1*1492:01 allele.  |  Gvozdjan, K., et al. 2023. HLA. 102: 648-650. PMID: 37515389
11. New HLA-DPB1 T-cell epitope model for mismatched UR-HCT.  |  Morishima, S. 2024. Blood. 144: 1659-1661. PMID: 39418035
12. A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules.  |  Kropshofer, H., et al. 1998. EMBO J. 17: 2971-81. PMID: 9606180

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HLA-DP β1 Antibody (7-RE35) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-HLA-DP β1 Antibody (7-RE35) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HLA-DP β1 Antibody (7-RE35) Specifications

Alternate Product Name: human leukocyte antigen (HLA) HLA-DPB1

Product Clone Name: 7-RE35

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-259

Epitope Target: HLA-DP β1

Epitope Species: human

Product Reactivity/Detection: HLA-DP β1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for HLA-DP β1 Antibody (7-RE35): N/A

The preferred HLA-DR/DP/DQ/DX antibody is HLA-DR/DP/DQ/DX Antibody (CR3/43): sc-53302.