HLA-D/DR/DQ Antibody (35): sc-53305
- HLA-D/DR/DQ Antibody (35) is a mouse monoclonal IgG3 κ HLA-D/DR/DQ antibody, cited in 1 publications, provided at 200 µg/ml
- raised against tumor fragments of mouse origin
- recommended for detection of HLA-D, HLA-DR and HLA-DQ of human origin by IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-D/DR/DQ Antibody (35). This work is in progress.
HLA-D/DR/DQ Antibody (35) is a mouse monoclonal IgG3 kappa light chain antibody designed to target the human HLA-D, HLA-DR, and HLA-DQ proteins, also known collectively as Human Leukocyte Antigen (HLA) Class II molecules. These proteins are integral components of the major histocompatibility complex (MHC) class II family, which play a crucial role in the immune system by presenting exogenous peptides to CD4+ helper T-cells, thereby initiating and regulating immune responses. This function is vital for the recognition of foreign antigens and the activation of adaptive immunity, making HLA-D/DR/DQ proteins essential in processes such as infection control and the development of autoimmune diseases. HLA-D/DR/DQ (35) monoclonal antibody is effective in various applications including immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM), ensuring versatile utility in research settings. Available in both non-conjugated form and multiple conjugated forms such as phycoerythrin (PE) and fluorescein isothiocyanate (FITC), anti-HLA-D/DR/DQ antibody (35) offers flexibility to meet diverse experimental requirements. HLA-D/DR/DQ (35) monoclonal antibody can effectively investigate the expression and function of MHC class II molecules, facilitating advancements in immunological research and the development of therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HLA-D/DR/DQ Antibody (35) References:
- HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus. | Siegmund, T., et al. 1999. Tissue Antigens. 54: 291-4. PMID: 10519369
- The association of HLA-DM genes with rheumatoid arthritis in Eastern France. | Toussirot, E., et al. 2000. Hum Immunol. 61: 303-8. PMID: 10689120
- Functional HLA-DM on the surface of B cells and immature dendritic cells. | Arndt, SO., et al. 2000. EMBO J. 19: 1241-51. PMID: 10716924
- Functional characterization of a lysosomal sorting motif in the cytoplasmic tail of HLA-DObeta. | Brunet, A., et al. 2000. J Biol Chem. 275: 37062-71. PMID: 10964920
- The down-regulation of HLA-DM gene expression in rheumatoid arthritis is not related to their promoter polymorphism. | Louis-Plence, P., et al. 2000. J Immunol. 165: 4861-9. PMID: 11046010
- Determination of the HLA-DM interaction site on HLA-DR molecules. | Doebele, RC., et al. 2000. Immunity. 13: 517-27. PMID: 11070170
- Association of colorectal tumor epithelium expressing HLA-D/DR with CD8-positive T-cells and mononuclear phagocytes. | Allen, CA. and Hogg, N. 1987. Cancer Res. 47: 2919-23. PMID: 3105871
- A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules. | Kropshofer, H., et al. 1998. EMBO J. 17: 2971-81. PMID: 9606180
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-D/DR/DQ Antibody (35) | sc-53305 | 200 µg/ml | $316.00 | |||
HLA-D/DR/DQ Antibody (35) FITC | sc-53305 FITC | 200 µg/ml | $330.00 | |||
HLA-D/DR/DQ Antibody (35) PE | sc-53305 PE | 200 µg/ml | $343.00 |