Histamine dihydrochloride is a potent vasodilator that acts as an agonist for endogenous histamine receptors (H1-4). The activation of histamine receptors mobilizes Ca2+ and stimulates adenylate cyclase activity in neurons. This compound can stimulate gastric secretion, constrict bronchial smooth muscle, act as a neurotransmitter, and activate nitric oxide.
1. Fu, L.W., et al. 1997. Am. J. Physiol. 273: H2726-H2737. PMID: 9435609 2. Maintz, L. and Novak, N. 2007. Am. J. Clin. Nutr. 85: 1185-1196. PMID: 17490952 3. Thurmond, R.L., et al. 2008. Nat Rev Drug Discov. 7: 41-53. PMID: 18172439
Soluble in water (100 mg/ml), ether, methanol (freely), and DMSO (100 mM).
Store at 4° C
0.63 g/cm3 at 20° C (tautomer)
n20D ~1.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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DengDeng, L. et al. (PubMed 26278136) reported that Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis. -SCBT Publication Review
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