Molecular structure of Hispidulin, CAS Number: 1447-88-7
Hispidulin (CAS 1447-88-7)
See product citations (7)
Alternate Names:
Dinatin; Scutellarein 6-methyl ether
Application:
Hispidulin is a potent benzodiazepine (BZD) receptor ligand
CAS Number:
1447-88-7
Molecular Weight:
300.27
Molecular Formula:
C16H12O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hispidulin is a natural flavanoid which acts as a potent benzodiazepine (BZD) receptor ligand. In addition, hispidulin competitively binds to the benzodiazepine receptor, thus inhibiting 3H-Flumazenil from binding to the receptor. Furthermore, it has been observed that hispidulin has antioxidant, antithrombotic, antifungal, and antiproliferative properties. Alternate studies indicate that hispidulin can inhibit the PI3K/Akt/mTOR signaling pathway in endothelial cells by targeting VEGF receptor 2. Inhibition of this receptor by hispidulin suppressed cell migration, invasion, and capillary-like structure formation of HU-VE-Cs in vascular endothelial cells. Hispidulin also aactivates AMPK.
Hispidulin (CAS 1447-88-7) References
- Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. | Kavvadias, D., et al. 2003. Planta Med. 69: 113-7. PMID: 12624814
- The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. | Kavvadias, D., et al. 2004. Br J Pharmacol. 142: 811-20. PMID: 15231642
- Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation. | Yang, JM., et al. 2010. J Agric Food Chem. 58: 10020-6. PMID: 20734985
- Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway. | He, L., et al. 2011. Cancer Sci. 102: 219-25. PMID: 21087351
- Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling. | Yu, CY., et al. 2013. Evid Based Complement Alternat Med. 2013: 518301. PMID: 24159347
- The effects of hispidulin on bupivacaine-induced neurotoxicity: role of AMPK signaling pathway. | Niu, X., et al. 2014. Cell Biochem Biophys. 70: 241-9. PMID: 24659139
- Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder cancer cells by targeting HIF-1α. | Gao, H., et al. 2015. Exp Cell Res. 332: 236-46. PMID: 25499970
- Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. | Bourdillat, B., et al. 1988. Eur J Pharmacol. 147: 1-6. PMID: 2836213
- Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARγ. | Han, M., et al. 2018. Biomed Pharmacother. 103: 272-283. PMID: 29656183
- Hispidulin inhibits adipogenesis in 3T3-L1 adipocytes through PPARγ pathway. | Lee, SG., et al. 2018. Chem Biol Interact. 293: 89-93. PMID: 30055130
- Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non‑small‑cell lung cancer cells. | Lv, L., et al. 2020. Oncol Rep. 43: 1995-2003. PMID: 32236602
- Anti-Proliferative and Anti-Migratory Activities of Hispidulin on Human Melanoma A2058 Cells. | Chang, CJ., et al. 2021. Biomolecules. 11: PMID: 34356663
- Hispidulin protection against hepatotoxicity induced by bromobenzene in mice. | Ferrándiz, ML., et al. 1994. Life Sci. 55: PL145-50. PMID: 8046988
Activator of:
AMPK, and GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hispidulin, 10 mg | sc-203999 | 10 mg | $250.00 | |||
Hispidulin, 100 mg | sc-203999A | 100 mg | $989.00 | |||
Hispidulin, 500 mg | sc-203999B | 500 mg | $3004.00 | |||
Hispidulin, 1 g | sc-203999C | 1 g | $5406.00 |