His-Cys-Lys-Phe-Trp-Trp (CAS 172546-75-7)

His-Cys-Lys-Phe-Trp-Trp is a hexapeptide that represents a specific sequence of amino acids, which is of significant interest in the study of protein structure and function. In research, this peptide can be synthesized to investigate the folding patterns and stability of polypeptide chains, providing insights into the factors that influence protein conformation. Due to the presence of tryptophan residues, this peptide is also valuable in fluorescence spectroscopy studies, where it can be used to explore protein interactions with ligands or other macromolecules, as tryptophan emits intrinsic fluorescence when excited. Researchers have investigated the ability of His-Cys-Lys-Phe-Trp-Trp to inhibit HIV-1 integrase (IN)-mediated 3′-processing and integration of HIV DNA. The specific amino acid sequence of His-Cys-Lys-Phe-Trp-Trp can be used as a model or scaffold for designing peptides with targeted biological activities, facilitating research in fields such as enzymatic catalysis, signal transduction, and molecular recognition.