HIPK1 Antibody (SR-5): sc-100382
- HIPK1 Antibody (SR-5) is a mouse monoclonal IgG2a κ HIPK1 antibody provided at 100 µg/ml
- raised against recombinant HIPK1 of human origin
- recommended for detection of HIPK1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HIPK1 Antibody (SR-5). This work is in progress.
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HIPK1 Antibody (SR-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects HIPK1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HIPK1 antibody (SR-5) is available as a non-conjugated monoclonal isotype antibody. The Homeodomain-Interacting Protein Kinase 1 (HIPK1) is a member of the HIPK family, which also includes HIPK2 and HIPK3, and these proteins are known for their roles as evolutionarily conserved nuclear serine/threonine kinases that interact with homeoproteins. HIPK1, a 1210 amino acid protein, is predominantly expressed in skeletal muscle and heart tissues, highlighting its significance in muscle function and cardiac health. HIPK1 is crucial for regulating various cellular processes, including transcriptional regulation and chromatin modification, and may act as a corepressor for homeodomain transcription factors. Notably, HIPK1 is involved in post-translational modifications, such as phosphorylation, which can influence its activity and interactions with other proteins, including Daxx, particularly in response to cellular stress. The presence of four isoforms resulting from alternative splicing events further underscores the complexity and regulatory potential of HIPK1 in various biological contexts, including its suggested involvement in malignant squamous cell tumor formation.
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HIPK1 Antibody (SR-5) References:
- Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. | Ecsedy, JA., et al. 2003. Mol Cell Biol. 23: 950-60. PMID: 12529400
- Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). | Kondo, S., et al. 2003. Proc Natl Acad Sci U S A. 100: 5431-6. PMID: 12702766
- Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. | Song, JJ. and Lee, YJ. 2003. J Biol Chem. 278: 47245-52. PMID: 12968034
- Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. | Li, X., et al. 2005. J Biol Chem. 280: 15061-70. PMID: 15701637
- DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. | Sekito, A., et al. 2006. Free Radic Res. 40: 155-65. PMID: 16390825
- Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. | Isono, K., et al. 2006. Mol Cell Biol. 26: 2758-71. PMID: 16537918
- Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. | Aikawa, Y., et al. 2006. EMBO J. 25: 3955-65. PMID: 16917507
- SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. | Li, X., et al. 2008. Cell Death Differ. 15: 739-50. PMID: 18219322
- Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. | Louie, SH., et al. 2009. PLoS One. 4: e4310. PMID: 19183803
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HIPK1 Antibody (SR-5) | sc-100382 | 100 µg/ml | $333.00 |