Hip1r Antibody (44): sc-135937
- Hip1r Antibody (44) is a mouse monoclonal IgG1 Hip1r antibody, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 560-772 of Hip1r of mouse origin
- recommended for detection of HIP12 of human origin, Hip1r of mouse origin and the corresponding rat and canine homologs by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Hip1r Antibody (44). This work is in progress.
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Hip1r Antibody (44) is a mouse monoclonal IgG1 antibody that detects Hip1r protein of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Hip1r antibody (44) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical protein. Hip1r monoclonal antibody (44) enables investigation of Hip1r′s vital role in vesicular trafficking, functioning as a component of clathrin-coated pits and vesicles, which are essential for the internalization of membrane proteins and lipids. This process is crucial for maintaining cellular homeostasis and regulating signaling pathways, as cells respond to external stimuli by modulating membrane composition. Hip1r (44) antibody helps reveal Hip1r′s interaction with the actin cytoskeleton, highlighting its importance in linking endocytic processes to cytoskeletal dynamics, thereby influencing cell shape and motility. Studies involving double knockout mice exhibit severe developmental defects and early mortality, indicating that Hip1r, along with its homolog Hip1, plays compensatory roles in cellular functions. Anti-Hip1r antibody (44) enables researchers to gain deeper insights into the mechanisms underlying vesicular trafficking and its implications in various diseases, including neurodegenerative disorders.
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Hip1r Antibody (44) References:
- The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro. | Engqvist-Goldstein, AE., et al. 2001. J Cell Biol. 154: 1209-23. PMID: 11564758
- HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains. | Hyun, TS., et al. 2004. J Biol Chem. 279: 14294-306. PMID: 14732715
- Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1. | Hyun, TS., et al. 2004. Mol Cell Biol. 24: 4329-40. PMID: 15121852
- Structural definition of the F-actin-binding THATCH domain from HIP1R. | Brett, TJ., et al. 2006. Nat Struct Mol Biol. 13: 121-30. PMID: 16415883
- Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1. | Bradley, SV., et al. 2007. Hum Mol Genet. 16: 1279-92. PMID: 17452370
- Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. | Wilbur, JD., et al. 2008. J Biol Chem. 283: 32870-9. PMID: 18790740
- Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1). | Seki, N., et al. 1998. J Hum Genet. 43: 268-71. PMID: 9852681
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hip1r Antibody (44) | sc-135937 | 50 µg/0.5 ml | $322.00 |