Hint2 Antibody (AT5B10): sc-517406

Hint2 Antibody (AT5B10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Hint2 protein of human origin by western blotting (WB), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Hint2 antibody (AT5B10) is available as a non-conjugated monoclonal isotype antibody. Hint2, also known as histidine triad nucleotide binding protein 2 or HIT-17, is a 163 amino acid secreted protein characterized by the presence of a HIT domain, which is crucial for catalytic activity toward the α-phosphate of ribonucleotides. This enzymatic function plays a role in nucleotide metabolism, influencing various cellular processes such as energy production and signal transduction. Hint2 is encoded by a gene located on chromosome 9, a region comprising 4% of the human genome and containing nearly 900 genes, with associations to several genetic disorders, including hereditary hemorrhagic telangiectasia and familial dysautonomia. Chromosome 9 contains the largest cluster of interferon family genes and participates in translocations with chromosome 22, leading to BCR-ABL fusion protein formation commonly implicated in certain leukemias. Hint2′s interaction with various cellular pathways underscores its importance in maintaining cellular homeostasis and highlights anti-Hint2 antibody (AT5B10)′s relevance in research and diagnostic applications.

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Hint2 Antibody (AT5B10) References:

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2. DNA sequence and analysis of human chromosome 9.  |  Humphray, SJ., et al. 2004. Nature. 429: 369-74. PMID: 15164053
3. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma.  |  Martin, J., et al. 2006. Gastroenterology. 130: 2179-88. PMID: 16762638
4. BCR-ABL activates STAT3 via JAK and MEK pathways in human cells.  |  Coppo, P., et al. 2006. Br J Haematol. 134: 171-9. PMID: 16846476
5. BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.  |  Zheng, X., et al. 2006. BMC Cancer. 6: 262. PMID: 17090304
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8. Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease).  |  Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
9. Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.  |  Burmeister, T., et al. 2007. Haematologica. 92: 1699-702. PMID: 18055996
10. HINT2 downregulation promotes colorectal carcinoma migration and metastasis.  |  Li, W., et al. 2017. Oncotarget. 8: 13521-13531. PMID: 28088787
11. The histidine triad nucleotide-binding protein 2 (HINT-2) positively regulates hepatocellular energy metabolism.  |  Rajasekaran, R., et al. 2018. FASEB J. 32: 5143-5161. PMID: 29913563
12. Histidine triad nucleotide-binding protein 2: From basic science to clinical implications.  |  Yao, J., et al. 2023. Biochem Pharmacol. 212: 115527. PMID: 37004779