HHV-8 K8.1A Antibody (2A3): sc-65445

HHV-8 K8.1A Antibody (2A3) is a mouse monoclonal IgG2a antibody that detects HHV-8 K8.1A protein of viral species reactivity by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). HHV-8 K8.1A plays a crucial role in the pathogenesis of Kaposi′s sarcoma-associated herpesvirus, as HHV-8 K8.1A is the predominant form associated with the virion envelope, consisting of 228 amino acids. HHV-8 K8.1A features a cleavable signal sequence, a transmembrane domain, and multiple glycosylation sites, including four N-glycosylation sites and O-glycosylation sites, which are essential for proper folding, stability, and function. These post-translational modifications influence HHV-8 K8.1A interactions with host cell receptors, particularly heparan sulfate molecules on the surface of target cells, thereby facilitating viral entry and infection. HHV-8 K8.1A glycoprotein′s ability to mediate these interactions underscores HHV-8 K8.1A importance in the viral lifecycle and potential as a target for therapeutic interventions. Anti-HHV-8 K8.1A antibody (2A3) serves as an invaluable tool for researchers studying the mechanisms of HHV-8 pathogenesis and the development of related diseases.

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HHV-8 K8.1A Antibody (2A3) References:

1. Comparison of human sera reactivities in immunoblots with recombinant human herpesvirus (HHV)-8 proteins associated with the latent (ORF73) and lytic (ORFs 65, K8.1A, and K8.1B) replicative cycles and in immunofluorescence assays with HHV-8-infected BCBL-1 cells.  |  Zhu, L., et al. 1999. Virology. 256: 381-92. PMID: 10191203
2. Characterization of human herpesvirus-8 K8.1A/B glycoproteins by monoclonal antibodies.  |  Zhu, L., et al. 1999. Virology. 262: 237-49. PMID: 10489357
3. A prospective seroepidemiological study of human herpesvirus-8 infection and the risk of multiple myeloma.  |  Tedeschi, R., et al. 2001. Br J Cancer. 84: 122-5. PMID: 11139326
4. Human herpesvirus 8 envelope glycoprotein K8.1A interaction with the target cells involves heparan sulfate.  |  Wang, FZ., et al. 2001. J Virol. 75: 7517-27. PMID: 11462024
5. Highly sensitive assay for human herpesvirus 8 antibodies that uses a multiple antigenic peptide derived from open reading frame K8.1.  |  Lam, LL., et al. 2002. J Clin Microbiol. 40: 325-9. PMID: 11825937
6. Human herpesvirus-8-encoded signalling ligands and receptors.  |  Nicholas, J. 2003. J Biomed Sci. 10: 475-89. PMID: 12928588
7. Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers.  |  Zhang, YJ., et al. 2007. Antiviral Res. 73: 12-23. PMID: 16842866
8. Human herpesvirus 8-encoded proteins with potential roles in virus-associated neoplasia.  |  Nicholas, J. 2007. Front Biosci. 12: 265-81. PMID: 17127298
9. Development of an immunofluorescence assay using recombinant proteins expressed in insect cells to screen and confirm presence of human herpesvirus 8-specific antibodies.  |  Minhas, V., et al. 2008. Clin Vaccine Immunol. 15: 1259-64. PMID: 18508931
10. Glycoprotein K8.1A of Kaposi's Sarcoma-Associated Herpesvirus Is a Critical B Cell Tropism Determinant Independent of Its Heparan Sulfate Binding Activity.  |  Dollery, SJ., et al. 2019. J Virol. 93: PMID: 30567992

The preferred HHV-8 K8.1A/B antibody is HHV-8 K8.1A/B Antibody (4A4): sc-65446.