Hh Signaling Antagonist VII, JK184 (CAS 315703-52-7)

Hh Signaling Antagonist VII, commonly known as JK184, is a potent inhibitor of the Hedgehog (Hh) signaling pathway, crucial in embryonic development and the regulation of cell growth and differentiation. JK184 specifically targets and inhibits the activity of the enzyme 7-dehydrocholesterol reductase (DHCR7), which is involved in the biosynthesis of cholesterol. By disrupting DHCR7, JK184 indirectly affects the production of cholesterol derivatives necessary for the proper functioning of the Hedgehog signaling pathway. This inhibition is significant as it allows researchers to study the pathway′s role in cell growth and development without the complications of associated pathologies. JK184 is particularly useful in developmental biology, where understanding the precise functions and regulations of signaling pathways like Hedgehog is essential. JK184 has been utilized to explore the molecular mechanisms by which the Hedgehog pathway influences tissue patterning and organogenesis. It has provided critical insights into the modulation of this pathway, offering a deeper understanding of cellular communication and the intricacies of developmental processes. Through these studies, JK184 aids in advancing knowledge on how fundamental signaling pathways direct complex biological systems.