Date published: 2026-4-25

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Hexestrol (CAS 84-16-2)

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Application:
Hexestrol is a synthetic estrogen inhibitor of microtubule polymerization
CAS Number:
84-16-2
Purity:
≥98%
Molecular Weight:
270.37
Molecular Formula:
C18H22O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hexestrol is an organic compound that has been the focus of extensive research due to its structural similarity to certain naturally occurring compounds. In the field of environmental science, hexestrol is studied for its potential effects on hormonal pathways in wildlife, providing insight into the impact of synthetic compounds on ecosystems. Chemists are interested in hexestrol′s ability to bind to various receptors, using it as a model to understand the structure-activity relationship in synthetic analogs. This compound is also a point of interest in materials science, where it may be incorporated into polymers or other materials to integrate specific optical properties, due to its unique structural configuration. Additionally, in biochemistry, hexestrol is utilized as a tool to probe the function of enzymes that interact with similar steroidal structures, which is for understanding metabolic pathways.


Hexestrol (CAS 84-16-2) References

  1. Effects of hexestrol on mouse ovarian morphology and ovulation.  |  de Oliveira, JM., et al. 2008. Maturitas. 60: 153-7. PMID: 18562135
  2. Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry.  |  Xu, Q., et al. 2011. Analyst. 136: 5030-7. PMID: 21994916
  3. Packed-fiber solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products.  |  Hu, WY., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 957: 7-13. PMID: 24636894
  4. Hexestrol- and nonylphenol-induced differential vitellogenin synthesis in female and male barfin plaice Liopsetta pinnifasciata.  |  Syasina, IG. and Shved, NA. 2015. Environ Toxicol Pharmacol. 39: 597-605. PMID: 25682006
  5. Electrochemical fabrication of polymerized imidazole-based ionic liquid bearing pyrrole moiety for sensitive determination of hexestrol in chicken meat.  |  Chen, X., et al. 2015. Food Chem. 180: 142-149. PMID: 25766811
  6. Development and validation of a confirmatory method for the determination of stilbene estrogens in ostrich serum.  |  Abafe, OA., et al. 2018. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 35: 458-466. PMID: 29210606
  7. Carcinogenicity and metabolic activation of hexestrol.  |  Liehr, JG., et al. 1985. Chem Biol Interact. 55: 157-76. PMID: 2998630
  8. Ruthenium oxide nanoparticles immobilized over Citrus limetta waste derived carbon material for electrochemical detection of hexestrol.  |  Chaudhary, K., et al. 2020. J Mater Chem B. 8: 7956-7965. PMID: 32756674
  9. Inhibition of microtubule polymerization by synthetic estrogens: formation of a ribbon structure.  |  Sato, Y., et al. 1987. J Biochem. 101: 1247-52. PMID: 3654591
  10. Antibacterial and antibiofilm efficacy of repurposing drug hexestrol against methicillin-resistant Staphylococcus aureus.  |  Liu, S., et al. 2023. Int J Med Microbiol. 313: 151578. PMID: 37001448
  11. Effect of hyperphysiological levels of hexestrol on the hepatic metabolism of nicotinate in the mouse.  |  Dietrich, LS., et al. 1970. Proc Soc Exp Biol Med. 133: 160-3. PMID: 4312713
  12. Carcinogenic antioxidants. Diethylstilboestrol, hexoestrol and 17 alpha-ethynyloestradiol.  |  Wiseman, H. and Halliwell, B. 1993. FEBS Lett. 332: 159-63. PMID: 8405434
  13. Metabolic activation and formation of DNA adducts of hexestrol, a synthetic nonsteroidal carcinogenic estrogen.  |  Jan, ST., et al. 1998. Chem Res Toxicol. 11: 412-9. PMID: 9585471

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hexestrol, 1 g

sc-205713
1 g
$97.00

Hexestrol, 5 g

sc-205713A
5 g
$291.00