Hexarelin (CAS 140703-51-1)
QUICK LINKS
Hexarelin is a synthetic hexapeptide that is primarily of interest in the field of endocrinology research. It functions as a ghrelin receptor agonist, which makes it a useful tool for studying the regulation of growth hormone release and appetite control mechanisms. In research applications, hexarelin is employed to understand the interactions between growth hormone secretagogues and their receptors, shedding light on the endogenous pathways that regulate these physiological processes. Furthermore, hexarelin is used in studies aimed at elucidating the role of ghrelin and its analogs in modulating cardiac function, as well as their potential effects on cardiac cells. In the realm of sports science and exercise physiology, the compound is investigated for its influences on muscle performance and metabolism. Additionally, hexarelin may be used in aging research to explore the implications of growth hormone secretagogues on age-related decline in growth hormone levels and associated physiological changes.
Hexarelin (CAS 140703-51-1) References
- Hexarelin as a test of pituitary reserve in patients with pituitary disease. | Korbonits, M., et al. 1999. Clin Endocrinol (Oxf). 51: 369-75. PMID: 10469018
- Hexarelin--evaluation of factors influencing oral bioavailability and ways to improve absorption. | Westberg, C., et al. 2001. J Pharm Pharmacol. 53: 1257-64. PMID: 11578108
- Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat. | Xu, X., et al. 2012. Am J Physiol Heart Circ Physiol. 303: H703-11. PMID: 22842067
- The cardiovascular action of hexarelin. | Mao, Y., et al. 2014. J Geriatr Cardiol. 11: 253-8. PMID: 25278975
- Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases. | Mosa, RM., et al. 2015. Endocrine. 49: 307-23. PMID: 25645463
- Hexarelin Protects Rodent Pancreatic Β-Cells Function from Cytotoxic Effects of Streptozotocin Involving Mitochondrial Signalling Pathways In Vivo and In Vitro. | Zhao, Y., et al. 2016. PLoS One. 11: e0149730. PMID: 26918825
- Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats. | Agbo, E., et al. 2019. Turk J Med Sci. 49: 945-958. PMID: 31091855
- Hexarelin attenuates atherosclerosis via inhibiting LOX-1-NF-κB signaling pathway-mediated macrophage ox-LDL uptake in ApoE-/- mice. | Cheng, XL., et al. 2019. Peptides. 121: 170122. PMID: 31386895
- Hexarelin protects cardiac H9C2 cells from angiotensin II-induced hypertrophy via the regulation of autophagy. | Agbo, E., et al. 2019. Pharmazie. 74: 485-491. PMID: 31526442
- Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats. | Baser, T., et al. 2021. Can J Physiol Pharmacol. 99: 461-467. PMID: 32893668
- Hexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide-Induced Apoptotic Toxicity. | Meanti, R., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34066741
- Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation. | Jiang, B., et al. 2022. Microvasc Res. 140: 104280. PMID: 34856183
- Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury. | Zambelli, V., et al. 2021. Drug Target Insights. 15: 26-33. PMID: 34871336
- Hexarelin stimulation of growth hormone release and mRNA levels in an infant and adult rat model of impaired GHRH function. | Torsello, A., et al. 1997. Neuroendocrinology. 65: 91-7. PMID: 9067986
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hexarelin, 1 mg | sc-394429 | 1 mg | $275.00 |