Date published: 2026-4-1

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Hexamethylene diisocyanate (CAS 822-06-0)

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Alternate Names:
1,6-Diisocyanatohexane
CAS Number:
822-06-0
Purity:
≥98%
Molecular Weight:
168.19
Molecular Formula:
C8H12N2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hexamethylene diisocyanate is a colorless liquid with a high boiling point. Belongs to the class of polyurethane precursors and is used as an intermediate in the production of polyurethane foams. It may act to form esters with various alcohols and amines, being chiral compounds they can be analyzed by electrochemical impedance spectroscopy. It is also used in the production of coatings, adhesives, and sealants.


Hexamethylene diisocyanate (CAS 822-06-0) References

  1. Modification of gelatin by reaction with 1,6-diisocyanatohexane.  |  Bertoldo, M., et al. 2007. Macromol Biosci. 7: 328-38. PMID: 17370271
  2. Allergic contact dermatitis from 1,6-diisocyanatohexane in an anti-pill finish.  |  Wilkinson, SM., et al. 1991. Contact Dermatitis. 25: 94-6. PMID: 1834431
  3. Use of aliphatic poly(amide urethane)s for the controlled release of 5-fluorouracil.  |  Sobczak, M., et al. 2011. Eur J Med Chem. 46: 914-8. PMID: 21292355
  4. Synthesis and characterization of X-ray opaque polycarbonate urethane: Effect of a dihalogenated chain extender on radiopacity and hemocompatibility.  |  Kiran, S. and Joseph, R. 2015. J Biomed Mater Res A. 103: 2214-24. PMID: 25345782
  5. Scaffolds of hydroxyl apatite nanoparticles disseminated in 1, 6-diisocyanatohexane-extended poly(1, 4-butylene succinate)/poly(methyl methacrylate) for bone tissue engineering.  |  Kaur, K., et al. 2017. Mater Sci Eng C Mater Biol Appl. 71: 780-790. PMID: 27987773
  6. Novel non-cytotoxic, bioactive and biodegradable hybrid materials based on polyurethanes/TiO2 for biomedical applications.  |  González-García, DM., et al. 2017. Mater Sci Eng C Mater Biol Appl. 75: 375-384. PMID: 28415475
  7. A high water-content and high elastic dual-responsive polyurethane hydrogel for drug delivery.  |  Li, J., et al. 2015. J Mater Chem B. 3: 8401-8409. PMID: 32262893
  8. Thermosensitive Micellar Hydrogels as Vehicles to Deliver Drugs With Different Wettability.  |  Laurano, R. and Boffito, M. 2020. Front Bioeng Biotechnol. 8: 708. PMID: 32766216
  9. An extracellular lipase from Amycolatopsis mediterannei is a cutinase with plastic degrading activity.  |  Tan, Y., et al. 2021. Comput Struct Biotechnol J. 19: 869-879. PMID: 33598102
  10. Thermoplastic zwitterionic elastomer with critical antifouling properties.  |  Wang, K., et al. 2022. Biomater Sci. 10: 2892-2906. PMID: 35446327
  11. The first space-filling polyhedrons of polymer cubic cells originated from Weaire-Phelan structure created by polymerization induced phase separation.  |  Naga, N., et al. 2022. Sci Rep. 12: 19141. PMID: 36351975
  12. Synthesis and characterization of non-invasively traceable poly(ether urethane)s for biomedical applications.  |  Karthika, VK., et al. 2023. Biomed Phys Eng Express. 9: PMID: 37100037
  13. Chitin-based poly(urea-urethane)s.  |  Muzzarelli, RA., et al. 1994. J Biomater Sci Polym Ed. 6: 541-7. PMID: 7873507

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hexamethylene diisocyanate, 250 ml

sc-252883
250 ml
$120.00

Hexamethylene diisocyanate, 1 L

sc-252883A
1 L
$386.00