Hexakis (2,3,6-tri-O-methyl)-α-cyclodextrin (CAS 68715-56-0)

Hexakis (2,3,6-tri-O-methyl)-α-cyclodextrin is a permethylated derivative of α-cyclodextrin where hydroxyl groups at the 2, 3, and 6 positions are substituted with methyl groups. This modification creates a hydrophobic cavity with distinct physicochemical properties, enhancing its ability to form stable inclusion complexes with various guest molecules. This derivative is particularly valuable in research involving molecular encapsulation, due to its hydrophobic core and methylated exterior, which allows for selective interactions with compounds of diverse chemical nature. In chromatographic separations, hexakis (2,3,6-tri-O-methyl)-α-cyclodextrin has shown significant efficacy as a chiral selector, helping distinguish and analyze stereoisomers in complex mixtures. The precise geometry and hydrophobic interactions enable researchers to probe enantioselective complexation mechanisms and their applications in the separation sciences. Moreover, in supramolecular chemistry and controlled release research, it is used to investigate the effects of permethylation on complexation kinetics, solubility, and molecular recognition. Its ability to encapsulate small molecules also makes it a useful model in studies of drug delivery, molecular transport, and the solubilization of hydrophobic substances in aqueous environments, contributing valuable data to the understanding of host-guest interactions.