Date published: 2026-4-24

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Hexafluoroisopropyl trifluoroacetate (CAS 42031-15-2)

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Alternate Names:
1,1,1,3,3,3-Hexafluoroisopropyl trifluoroacetate
CAS Number:
42031-15-2
Molecular Weight:
264.05
Molecular Formula:
C5HF9O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hexafluoroisopropyl trifluoroacetate, also known as HFA-TFA, is a chemical compound belonging to the class of organofluorine compounds. It is derived from trifluoroacetic acid and contains a hexafluoroisopropyl group. Hexafluoroisopropyl trifluoroacetate is a colorless liquid with a strong odor. It is primarily used as a reagent in organic synthesis, particularly in the introduction of the hexafluoroisopropyl group into organic molecules. The hexafluoroisopropyl group imparts unique properties to the resulting compounds, such as increased lipophilicity and chemical stability. Hexafluoroisopropyl trifluoroacetate is often employed in pharmaceutical and agrochemical research for the modification and design of new compounds with desired properties.


Hexafluoroisopropyl trifluoroacetate (CAS 42031-15-2) References

  1. Radiofluorination of a pre-formed gallium(III) aza-macrocyclic complex: towards next-generation positron emission tomography (PET) imaging agents.  |  Bhalla, R., et al. 2015. Chemistry. 21: 4688-94. PMID: 25652736
  2. Analysis of bile acids in human biological samples by microcolumn separation techniques: A review.  |  Dosedělová, V., et al. 2021. Electrophoresis. 42: 68-85. PMID: 32645223

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hexafluoroisopropyl trifluoroacetate, 25 g

sc-300794
25 g
$320.00