Date published: 2026-4-5

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Hexafluorobenzene (CAS 392-56-3)

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Alternate Names:
Perfluorobenzene
CAS Number:
392-56-3
Molecular Weight:
186.05
Molecular Formula:
C6F6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hexafluorobenzene (HFB) is a perfluorinated compound, possessing diverse applications in chemistry, biochemistry, and material science. It is a clear, volatile liquid with a distinct, pleasant scent. Acting as a intermediary, Hexafluorobenzene aids in the production of various organic compounds like dyes and pigments. Additionally, it serves as a key component in the synthesis of polymers, surfactants, and other materials. In the realm of scientific research, Hexafluorobenzene finds wide-ranging utility as a reagent in organic synthesis, a solvent for chemical reactions, and a starting point for the creation of fluorinated compounds. Furthermore, it plays a significant role in the generation of organofluorine compounds, including fluorinated alcohols and ethers. For reactions. eg. Grignards: J.Organomet.


Hexafluorobenzene (CAS 392-56-3) References

  1. Hexafluorobenzene photochemistry: wellspring of fluorocarbon structures.  |  Lemal, DM. 2001. Acc Chem Res. 34: 662-71. PMID: 11513574
  2. Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility.  |  Antognini, JF., et al. 2007. Anesth Analg. 104: 822-8. PMID: 17377088
  3. The two structures of the hexafluorobenzene radical cation C6F6(*+).  |  Shorafa, H., et al. 2009. Angew Chem Int Ed Engl. 48: 5845-7. PMID: 19582741
  4. Hexafluorobenzene: a powerful solvent for a noncovalent stereoselective organocatalytic Michael addition reaction.  |  Lattanzi, A., et al. 2012. Chem Commun (Camb). 48: 1650-2. PMID: 22190150
  5. Hexafluorobenzene in comparison with perfluoro-15-crown-5-ether for repeated monitoring of oxygenation using 19F MRI in a mouse model.  |  Mignion, L., et al. 2013. Magn Reson Med. 69: 248-54. PMID: 22442096
  6. Photophysics of fluorinated benzene. III. Hexafluorobenzene.  |  Mondal, T., et al. 2012. J Chem Phys. 137: 054311. PMID: 22894352
  7. Hexafluorobenzene under Extreme Conditions.  |  Pravica, M., et al. 2016. J Phys Chem B. 120: 2854-8. PMID: 26910443
  8. Synthesis of Fluorine-Doped Hydrophilic Carbon Nanoparticles from Hexafluorobenzene by Femtosecond Laser Pulses.  |  Okamoto, T., et al. 2017. Chemphyschem. 18: 1007-1011. PMID: 27557055
  9. High-Temperature Reactions of Hexafluorobenzene.  |  Antonucci, JM. and Wall, LA. 1966. J Res Natl Bur Stand A Phys Chem. 70A: 473-480. PMID: 31824014
  10. IR absorption spectra of hexafluorobenzene anions and pentafluorophenyl radicals in solid argon.  |  Chou, SL., et al. 2021. Spectrochim Acta A Mol Biomol Spectrosc. 252: 119524. PMID: 33582441
  11. Role of the Perfluoro Effect in the Selective Photochemical Isomerization of Hexafluorobenzene.  |  Cox, JM., et al. 2021. J Am Chem Soc. 143: 7002-7012. PMID: 33938749
  12. Temperature-Dependent Photoluminescence of Hexafluorobenzene-Intercalated Phenethylammonium Tin Iodide 2D Perovskite.  |  Dutta, T., et al. 2021. Chem Asian J. 16: 2745-2751. PMID: 34342155
  13. Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation.  |  Mason, RP., et al. 1996. NMR Biomed. 9: 125-34. PMID: 8892399

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hexafluorobenzene, 5 g

sc-257584
5 g
$39.00

Hexafluorobenzene, 25 g

sc-257584A
25 g
$125.00