Date published: 2026-4-5

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Hexachlorobenzene (CAS 118-74-1)

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Alternate Names:
Perchlorobenzene
CAS Number:
118-74-1
Molecular Weight:
284.78
Molecular Formula:
C6Cl6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hexachlorobenzene is a stable, white, crystalline substance that has been used as a fungicide and in the manufacture of dyes, organic chemicals, rubber, and wood preservation. When heated, it emits toxic fumes including carbon monoxide, carbon dioxide, hydrochloric acid, and other chlorinated compounds. In the past, hexachlorobenzene was widely used as a pesticide for protecting onion and sorghum seeds, as well as in the production of fireworks, ammunition, and synthetic rubber. Research has shown that hexachlorobenzene activates specific signaling pathways and promotes cell migration and the expression of metalloproteases (MMPs), which play a role in tumor invasion and metastasis. In animal models, hexachlorobenzene has been found to enhance tumor growth and increase the expression of MMP2 and MMP9 proteins. Furthermore, it stimulates lung metastasis, regardless of the tumor′s hormone-receptor status.


Hexachlorobenzene (CAS 118-74-1) References

  1. The role of the immune system in hexachlorobenzene-induced toxicity.  |  Michielsen, CC., et al. 1999. Environ Health Perspect. 107 Suppl 5: 783-92. PMID: 10502545
  2. Environmental toxicology and health effects associated with hexachlorobenzene exposure.  |  Reed, L., et al. 2007. Rev Environ Health. 22: 213-43. PMID: 18078005
  3. Hexachlorobenzene sources, levels and human exposure in the environment of China.  |  Wang, G., et al. 2010. Environ Int. 36: 122-130. PMID: 19818502
  4. Biomonitoring equivalents for hexachlorobenzene.  |  Aylward, LL., et al. 2010. Regul Toxicol Pharmacol. 58: 25-32. PMID: 20547196
  5. Hexachlorobenzene as a persistent organic pollutant: Toxicity and molecular mechanism of action.  |  Starek-Świechowicz, B., et al. 2017. Pharmacol Rep. 69: 1232-1239. PMID: 29128804
  6. The history of hexachlorobenzene accumulation in Svalbard fjords.  |  Pouch, A., et al. 2018. Environ Monit Assess. 190: 360. PMID: 29799069
  7. Hexachlorobenzene.  |  . 1988. Rev Environ Contam Toxicol. 106: 143-54. PMID: 3059406
  8. Hexachlorobenzene Catabolism Involves a Nucleophilic Aromatic Substitution and Flavin-N5-Oxide Formation.  |  Adak, S. and Begley, TP. 2019. Biochemistry. 58: 1181-1183. PMID: 30702280
  9. Hexachlorobenzene: an ecotoxicological profile of an organochlorine compound.  |  Bro-Rasmussen, F. 1986. IARC Sci Publ. 231-42. PMID: 3298032
  10. Environmental health risk assessment: hexachlorobenzene.  |  Krewski, D., et al. 1986. IARC Sci Publ. 621-8. PMID: 3298040
  11. Toxicity studies of hexachlorobenzene administered by gavage to female Sprague Dawley (Hsd:Sprague Dawley SD) rats.  |  ,. 2021. Toxic Rep Ser.. PMID: 33687031
  12. The endocrine disruptor hexachlorobenzene can cause oxidative damage in the testis of mice.  |  Dou, L., et al. 2021. Andrologia. 53: e14195. PMID: 34374107
  13. Photochemical transformation of hexachlorobenzene (HCB) in solid-water system: Kinetics, mechanism and toxicity evaluation.  |  Tu, Z., et al. 2022. Chemosphere. 295: 133907. PMID: 35151701
  14. Mechanochemical treatment of hexachlorobenzene-contaminated soil with additives.  |  Li, X. and Chen, H. 2023. Environ Sci Pollut Res Int. 30: 41910-41922. PMID: 36639587
  15. Hexachlorobenzene as a possible major contributor to the dioxin activity of human milk.  |  van Birgelen, AP. 1998. Environ Health Perspect. 106: 683-8. PMID: 9799183

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hexachlorobenzene, 250 mg

sc-255196
250 mg
$53.00

Hexachlorobenzene, 25 g

sc-255196A
25 g
$378.00