Hex Antibody (HHE5I261): sc-81284

Hex Antibody (HHE5I261) is a mouse monoclonal IgG1 antibody that detects the Hex protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Hex antibody (HHE5I261) is available as the non-conjugated format. The homeobox protein Hex, also known as proline-rich homeodomain protein (Prh), is encoded by a divergent homeobox gene that is transiently expressed in various hematopoietic lineages, indicating a crucial role in cellular differentiation. Hex (HHE5I261) antibody recognizes a protein particularly important due to involvement in the differentiation of vascular endothelial cells and the development and maintenance of several organs derived from foregut endoderm, including the lung, liver, and thyroid gland. Hex is expressed during the developmental phases of these organs and continues to be present in adult tissues such as the thyroid, lung, and liver. Additionally, Hex mediates the transcriptional induction of the SMemb/NMHC-B gene through its homeodomain and acts as a transcriptional modulator of cAMP response element-dependent transcription in vascular smooth muscle cells. As a soluble protein, Hex is localized in both the nucleus and cytoplasm of cultured cells, which underscores a multifaceted role in gene regulation and cellular processes.

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Hex Antibody (HHE5I261) References:

1. The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.  |  Martinez Barbera, JP., et al. 2000. Development. 127: 2433-45. PMID: 10804184
2. Expression and function of the homeodomain-containing protein Hex in thyroid cells.  |  Pellizzari, L., et al. 2000. Nucleic Acids Res. 28: 2503-11. PMID: 10871399
3. Divergent homeobox gene hex regulates promoter of the Na(+)-dependent bile acid cotransporter.  |  Denson, LA., et al. 2000. Am J Physiol Gastrointest Liver Physiol. 279: G347-55. PMID: 10915644
4. Hex expression suggests a role in the development and function of organs derived from foregut endoderm.  |  Bogue, CW., et al. 2000. Dev Dyn. 219: 84-9. PMID: 10974674
5. Immunocytochemical characterization of murine Hex, a homeobox-containing protein.  |  Ghosh, B., et al. 2000. Pediatr Res. 48: 634-8. PMID: 11044484
6. Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element.  |  Sekiguchi, K., et al. 2001. Circ Res. 88: 52-8. PMID: 11139473

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hex Antibody (HHE5I261) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Hex Antibody (HHE5I261) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hex Antibody (HHE5I261) Specifications

Alternate Product Name: Hex

Product Clone Name: HHE5I261

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Hex

Epitope Species: human

Product Reactivity/Detection: Hex

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Hex Antibody (HHE5I261): N/A