Date published: 2025-11-2

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Hesperidin methyl chalcone (CAS 24292-52-2)

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Alternate Names:
Hesperidin methylchalcone; (E)-1-[4-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one
CAS Number:
24292-52-2
Molecular Weight:
624.59
Molecular Formula:
C29H36O15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hesperidin methyl chalcone is a flavonoid present in citrus fruits like oranges, lemons, and tangerines. Recognized for its polyphenolic structure, Hesperidin methyl chalcone has garnered attention in research for its antioxidant capabilities and influence on inflammatory responses. It has shown promise in scientific studies exploring its effects on cellular signaling and gene expression related to oxidative stress and cellular regulation.


Hesperidin methyl chalcone (CAS 24292-52-2) References

  1. Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage.  |  Martinez, RM., et al. 2015. J Photochem Photobiol B. 148: 145-153. PMID: 25916506
  2. Combination of Ruscus aculeatus extract, hesperidin methyl chalcone and ascorbic acid: a comprehensive review of their pharmacological and clinical effects and of the pathophysiology of chronic venous disease.  |  Allaert, FA. 2016. Int Angiol. 35: 111-6. PMID: 26928296
  3. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease.  |  Jawien, A., et al. 2017. Int Angiol. 36: 31-41. PMID: 28124877
  4. Hesperidin methyl chalcone alleviates spinal tuberculosis in New Zealand white rabbits by suppressing immune responses.  |  Zhao, Y., et al. 2020. J Spinal Cord Med. 43: 532-539. PMID: 30124375
  5. Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation.  |  Rasquel-Oliveira, FS., et al. 2020. Inflammopharmacology. 28: 979-992. PMID: 32048121
  6. Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis.  |  Guazelli, CFS., et al. 2021. Chem Biol Interact. 333: 109315. PMID: 33171134
  7. Systematic literature review and network Meta-analysis of sulodexide and other drugs in chronic venous disease.  |  Pompilio, G., et al. 2021. Phlebology. 36: 695-709. PMID: 33983078
  8. Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells.  |  Monjotin, N. and Tenca, G. 2022. Microvasc Res. 139: 104274. PMID: 34717967
  9. The Flavonoid Hesperidin Methyl Chalcone Targets Cytokines and Oxidative Stress to Reduce Diclofenac-Induced Acute Renal Injury: Contribution of the Nrf2 Redox-Sensitive Pathway.  |  Bussmann, AJC., et al. 2022. Antioxidants (Basel). 11: PMID: 35883752
  10. Hesperidin Methyl Chalcone: An Emerging Compound for the Treatment of Inflammation and Pain.  |  Borghi, SM., et al. 2023. Curr Med Chem. 30: 601-603. PMID: 35996246
  11. Hesperidin methyl chalcone ameliorates lipid metabolic disorders by activating lipase activity and increasing energy metabolism.  |  Liu, S., et al. 2023. Biochim Biophys Acta Mol Basis Dis. 1869: 166620. PMID: 36494040
  12. Hesperidin Methyl Chalcone Reduces the Arthritis Caused by TiO2 in Mice: Targeting Inflammation, Oxidative Stress, Cytokine Production, and Nociceptor Sensory Neuron Activation.  |  Artero, NA., et al. 2023. Molecules. 28: PMID: 36677929
  13. Hesperidin methyl chalcone, a citrus flavonoid, inhibits Aeromonas hydrophila infection mediated by quorum sensing.  |  Roshni, PS., et al. 2023. Microb Pathog. 177: 106029. PMID: 36775212

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hesperidin methyl chalcone, 25 g

sc-235288
25 g
$79.00

Hesperidin methyl chalcone, 250 g

sc-235288A
250 g
$408.00

Hesperidin methyl chalcone, 1 kg

sc-235288B
1 kg
$1020.00