Molecular structure of Hesperetin, CAS Number: 69097-99-0
Hesperetin (CAS 69097-99-0)
See product citations (14)
Alternate Names:
3′,5,7-Trihydroxy-4′-methoxyflavanone; 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone; Cyanidanon 4′-methyl ether 1626
Application:
Hesperetin is a dietary flavanone with chemopreventive effect
CAS Number:
69097-99-0
Purity:
≥95%
Molecular Weight:
302.28
Molecular Formula:
C16H14O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Hesperetin functions as an antioxidant in experimental applications. It exerts its mechanism of action by scavenging free radicals and inhibiting oxidative stress at the molecular level. Hesperetin may modulate various cellular signaling pathways, including those involved in inflammation and cell proliferation. Its ability to chelate metal ions contributes to its antioxidant properties, further enhancing its role in reducing oxidative damage. Hesperetin interacts with enzymes involved in the regulation of cellular processes, potentially influencing gene expression and protein synthesis. These molecular interactions highlight the functional role of hesperetin as an antioxidant compound with the capacity to modulate cellular responses to oxidative stress in experimental applications.
Hesperetin (CAS 69097-99-0) References
- Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. | Parhiz, H., et al. 2015. Phytother Res. 29: 323-31. PMID: 25394264
- Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model. | Ikram, M., et al. 2019. Mol Neurobiol. 56: 6293-6309. PMID: 30756299
- Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling. | Muhammad, T., et al. 2019. Nutrients. 11: PMID: 30884890
- Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis. | Chen, X., et al. 2019. Chem Biol Interact. 308: 269-278. PMID: 31153982
- Hesperetin ameliorates DSS-induced colitis by maintaining the epithelial barrier via blocking RIPK3/MLKL necroptosis signaling. | Zhang, J., et al. 2020. Eur J Pharmacol. 873: 172992. PMID: 32035144
- Hesperetin's health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations. | Salehi, B., et al. 2022. Crit Rev Food Sci Nutr. 62: 4449-4464. PMID: 33491467
- Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis. | Liu, P., et al. 2021. Biomed Pharmacother. 139: 111552. PMID: 33839495
- Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. | Li, J., et al. 2021. Food Funct. 12: 3898-3918. PMID: 33977953
- Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway. | Zhu, X., et al. 2021. Metab Brain Dis. 36: 1969-1983. PMID: 34273043
- Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health. | Ortiz, AC., et al. 2022. Biomolecules. 12: PMID: 35625554
- Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review. | Yang, H., et al. 2022. J Agric Food Chem. 70: 8582-8592. PMID: 35801973
- Hesperetin attenuates UVA-induced photodamage in human dermal fibroblast cells. | Lu, Z., et al. 2022. J Cosmet Dermatol. 21: 6261-6269. PMID: 35816390
- Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways. | Zalpoor, H., et al. 2022. Inflammopharmacology. 30: 1533-1539. PMID: 35994216
Inhibitor of:
BMP-2, Myogenin, and Sox-21.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hesperetin, 1 g | sc-252878 | 1 g | $36.00 |