Date published: 2026-3-18

1-800-457-3801

SCBT Portrait Logo
Seach Input

Heraclenin (CAS 2880-49-1)

0.0(0)
Write a reviewAsk a question

CAS Number:
2880-49-1
Molecular Weight:
286.3
Molecular Formula:
C16H14O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Heraclenin inhibits T cell-receptor-mediated proliferation in human primary T cells in a concentration-dependent manner. Heraclenin also induces apoptosis. While imperatorin induces DNA fragmentation at the G1/S phase of the cell cycle, heraclenin induces DNA fragmentation at the G2/M phases of the cell cycle, thus despite a close structural similarity they induce apoptosis in mechanistically different ways.


Heraclenin (CAS 2880-49-1) References

  1. Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model.  |  García-Argáez, AN., et al. 2000. Planta Med. 66: 279-81. PMID: 10821059
  2. Coumarins from the aerial part of Halocnemum strobilaceum.  |  Miftakhova, AF., et al. 2001. Fitoterapia. 72: 319-21. PMID: 11295318
  3. HPLC-NMR/HPLC-MS analysis of the bark extract of Stauranthus perforatus.  |  Setzer, WN., et al. 2003. Phytochem Anal. 14: 54-9. PMID: 12597256
  4. Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin.  |  Appendino, G., et al. 2004. J Nat Prod. 67: 532-6. PMID: 15104479
  5. Candibirin A, a furanocoumarin dimer isolated from Heracleum candicans WALL.  |  Doi, M., et al. 2004. Acta Crystallogr C. 60: o833-5. PMID: 15528835
  6. Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT.  |  Márquez, N., et al. 2004. Planta Med. 70: 1016-21. PMID: 15549655
  7. Nematicidal coumarins from Heracleum candicans Wall.  |  Wang, XB., et al. 2008. Nat Prod Res. 22: 666-71. PMID: 18569707
  8. Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms.  |  Froldi, G., et al. 2011. J Ethnopharmacol. 134: 637-43. PMID: 21236328
  9. In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells.  |  Kimura, Y., et al. 2013. Photochem Photobiol. 89: 1216-25. PMID: 23802687
  10. Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia.  |  Mottaghipisheh, J., et al. 2018. Pharm Biol. 56: 658-664. PMID: 31070540
  11. Osteogenic stimulatory effect of heraclenin purified from bael in mouse mesenchymal stem cells in vitro.  |  Shanmugam, H., et al. 2019. Chem Biol Interact. 310: 108750. PMID: 31319076
  12. Mutagenicity of a furocoumarin epoxide, heraclenin, in Chlamydomonas reinhardii.  |  Schimmer, O. and Abel, G. 1986. Mutat Res. 169: 47-50. PMID: 3945236
  13. Chromosome-damaging effects of heraclenin in human lymphocytes in vitro.  |  Abel, G. and Schimmer, O. 1986. Mutat Res. 169: 51-4. PMID: 3945237
  14. Anticoagulant activity of Heraclenin.  |  Mishra, KC., et al. 1969. Indian J Physiol Pharmacol. 13: 153-5. PMID: 5362630

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Heraclenin, 5 mg

sc-391029
5 mg
$600.00