Molecular structure of Heptafluorobutyric acid, CAS Number: 375-22-4
Heptafluorobutyric acid (CAS 375-22-4)
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Alternate Names:
Perfluorobutyric acid
Application:
Heptafluorobutyric acid is an anion-pairing agent for reverse phase HPLC purification of proteins & peptides
CAS Number:
375-22-4
Purity:
≥99%
Molecular Weight:
214.04
Molecular Formula:
C4HF7O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Heptafluorobutyric acid is an anion-pairing agent for reverse phase HPLC purification of proteins and peptides. Heptafluorobutyric acid, classified as a perfluorochemical (PFC), is an environmental pollutant that is encountered due to its widespread use in numerous industrial and commercial sectors. These applications include fire-fighting foams, coatings for paper, leather, and textiles, as well as utilization in polymer industries, among others. Moreover, heptafluorobutyric acid serves as an efficient additive in zinc electrodeposition processes. Additionally, it finds application as a chromatographic reagent and is recognized as a xenobiotic compound. Its origin stems from butyric acid, undergoing modification through fluorination.
Heptafluorobutyric acid (CAS 375-22-4) References
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- Quantification of amino acid ionic liquids using liquid chromatography-mass spectrometry. | Tang, F., et al. 2008. J Chromatogr A. 1208: 175-81. PMID: 18790488
- Separation of Amadori peptides from their unmodified analogs by ion-pairing RP-HPLC with heptafluorobutyric acid as ion-pair reagent. | Frolov, A. and Hoffmann, R. 2008. Anal Bioanal Chem. 392: 1209-14. PMID: 18813915
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- Cooperative effect in ion pairing of oligolysine with heptafluorobutyric acid in reversed-phase chromatography. | Xie, W., et al. 2011. J Chromatogr A. 1218: 7765-70. PMID: 21937049
- Multi-residue determination of antibiotics in fish by liquid chromatography-tandem mass spectrometry. | Gbylik, M., et al. 2013. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30: 940-8. PMID: 23573832
- Comparison of retention behavior of oligolysine and oligoarginine in ion-pairing chromatography using heptafluorobutyric acid. | Xie, W., et al. 2013. Anal Bioanal Chem. 405: 9739-46. PMID: 24114467
- An integrated electrophoretic mobility control device with split design for signal improvement in liquid chromatography-electrospray ionization mass spectrometry analysis of aminoglycosides using a heptafluorobutyric acid containing mobile phase. | Hung, SH., et al. 2016. Anal Chim Acta. 933: 156-63. PMID: 27497008
- Novel Experimental-Modeling Approach for Characterizing Perfluorinated Surfactants in Soils. | Courtier-Murias, D., et al. 2017. Environ Sci Technol. 51: 2602-2610. PMID: 28165731
- Modulator-Mediated Functionalization of MOF-808 as a Platform Tool to Create High-Performance Mixed-Matrix Membranes. | Thür, R., et al. 2019. ACS Appl Mater Interfaces. 11: 44792-44801. PMID: 31687797
- Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma. | Roseboom, IC., et al. 2020. J Pharm Biomed Anal. 185: 113245. PMID: 32199328
- Fluorinated carboxylic acids as 'ion repelling agents' in reversed-phase chromatography. | Lajin, B. and Goessler, W. 2020. J Chromatogr A. 1631: 461575. PMID: 32987313
- Systemic toxicity induced by topical application of heptafluorobutyric acid (PFBA) in a murine model. | Weatherly, LM., et al. 2021. Food Chem Toxicol. 156: 112528. PMID: 34474067
- Effect of mobile phase pH on liquid chromatography retention of mepartricin related compounds and impurities as support to the structural investigation by liquid chromatography-mass spectrometry. | Tengattini, S., et al. 2022. J Pharm Biomed Anal. 220: 114971. PMID: 35970110
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Heptafluorobutyric acid, 5 ml | sc-250088 | 5 ml | $52.00 | |||
Heptafluorobutyric acid, 25 ml | sc-250088A | 25 ml | $182.00 |