Hep G2 + TGFβ Cell Lysate: sc-24702

The Hep G2 + TGFβ Cell Lysate is derived from the Hep G2 cell line, a well-established human liver carcinoma line originally sourced from a 15-year-old Caucasian male with hepatoblastoma. This lysate, treated with Transforming Growth Factor-beta (TGFβ), is used extensively in scientific research to study the molecular pathways of liver carcinogenesis and fibrosis. TGFβ is known to play a critical role in cellular processes such as proliferation, differentiation, and extracellular matrix production. When Hep G2 cells are treated with TGFβ, it induces epithelial-mesenchymal transition (EMT), a process crucial for cancer metastasis. Researchers utilize this lysate to examine changes in protein expression, signaling pathways, and gene regulation associated with TGFβ-induced EMT. Studies frequently employ this lysate in Western blotting, mass spectrometry, and proteomics to identify key proteins involved in TGFβ signaling. Additionally, it serves as a model for investigating the effects of chemical activators or inhibitors on TGFβ pathways. The Hep G2 + TGFβ Cell Lysate provides a robust system for exploring the molecular mechanisms underlying liver disease progression, aiding in the identification of novel biomarkers and potential targets for further research in cancer biology and liver pathology.