Hep E Antibody (S-13): sc-69657

Hep E Antibody (S-13) is a mouse monoclonal IgM antibody that detects the Hep E protein of Hep E origin by enzyme-linked immunosorbent assay (ELISA). Anti-Hep E antibody (S-13) is available as the non-conjugated format, providing a reliable tool for researchers studying this significant pathogen. Hepatitis E is a gastroenterological disease that can lead to severe health complications, particularly in pregnant women, where the mortality rate can reach 20% in those more than six months pregnant. Hep E protein plays a crucial role in the virus′s lifecycle, particularly due to its RNA-directed RNA polymerase (RdRp) catalytic domain, which is essential for viral replication. This domain not only facilitates the synthesis of the viral RNA genome but also enables the production of complementary RNA strands necessary for virus propagation. Understanding the function of Hep E protein and its RdRp domain is vital for developing therapeutic strategies and vaccines against Hepatitis E, a disease primarily transmitted through fecal contamination of food and water supplies. The Hep E virion, characterized by its round, non-enveloped, isometric capsid with a diameter of 27-34 nm, encapsulates a single-stranded, positive-sense RNA genome of approximately 4.5 kb, underscoring the complexity and resilience of this virus. Hep E monoclonal antibody (S-13) can help advance studies on Hepatitis E, contributing to the broader understanding of viral hepatitis and its impact on public health.

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Hep E Antibody (S-13) References:

1. Hepatitis E.  |  Krawczynski, K., et al. 2000. Infect Dis Clin North Am. 14: 669-87. PMID: 10987115
2. Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries.  |  Meng, XJ., et al. 2002. J Clin Microbiol. 40: 117-22. PMID: 11773103
3. Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV).  |  Huang, CC., et al. 1992. Virology. 191: 550-8. PMID: 1448913
4. Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.  |  Koonin, EV., et al. 1992. Proc Natl Acad Sci U S A. 89: 8259-63. PMID: 1518855
5. Hepatitis E virus: identification of type-common epitopes.  |  Yarbough, PO., et al. 1991. J Virol. 65: 5790-7. PMID: 1717709
6. Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome.  |  Tam, AW., et al. 1991. Virology. 185: 120-31. PMID: 1926770
7. Hepatitis E virus.  |  Abravanel, F., et al. 2013. Med Mal Infect. 43: 263-70. PMID: 23608595
8. Hepatitis E: Epidemiology, Clinical Course, Prevention, and Treatment.  |  Goel, A. and Aggarwal, R. 2020. Gastroenterol Clin North Am. 49: 315-330. PMID: 32389365
9. Seroreactivity to hepatitis E virus in areas where the disease is not endemic.  |  Thomas, DL., et al. 1997. J Clin Microbiol. 35: 1244-7. PMID: 9114415
10. A novel virus in swine is closely related to the human hepatitis E virus.  |  Meng, XJ., et al. 1997. Proc Natl Acad Sci U S A. 94: 9860-5. PMID: 9275216
11. The sequence and phylogenetic analysis of a novel hepatitis E virus isolated from a patient with acute hepatitis reported in the United States.  |  Schlauder, GG., et al. 1998. J Gen Virol. 79 (Pt 3): 447-56. PMID: 9519822
12. Genetic and experimental evidence for cross-species infection by swine hepatitis E virus.  |  Meng, XJ., et al. 1998. J Virol. 72: 9714-21. PMID: 9811705