Hep C NS5b Antibody (1826): sc-58146

Hep C NS5b Antibody (1826) is a mouse monoclonal IgG1 antibody that detects the Hep C NS5b protein of Hepatitis C virus origin by western blotting (WB) and immunofluorescence (IF). Hep C NS5b (1826) antibody is available as the non-conjugated format. Hep C NS5b functions as an RNA-dependent RNA polymerase (RdRp), which is crucial for the replication of the viral RNA genome, making Hep C NS5b (1826) monoclonal antibody a key target for therapeutic intervention in Hepatitis C virus infections. Hep C NS5b′s ability to synthesize RNA from an RNA template is vital for the virus′s life cycle, as this process ensures the production of new viral genomes necessary for viral propagation within the host. Anti-Hep C NS5b antibody (1826) recognizes a protein that extends beyond enzymatic activity as a target for antiviral drugs, where inhibiting NS5b function can effectively reduce viral load and improve patient outcomes. Understanding Hep C NS5b′s role in viral replication is essential for developing effective treatments and vaccines against Hepatitis C, a major global health concern.

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Hep C NS5b Antibody (1826) References:

1. The non-structural 5A protein of hepatitis C virus.  |  Pawlotsky, JM. and Germanidis, G. 1999. J Viral Hepat. 6: 343-56. PMID: 10607250
2. Genomic variability of hepatitis G virus/GBV-C at the NS3 region: clinical implications.  |  García, F., et al. 2000. Microbios. 102: 17-25. PMID: 10817517
3. Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.  |  Lohmann, V., et al. 2000. J Viral Hepat. 7: 167-74. PMID: 10849258
4. Characterization of monoclonal antibodies that specifically recognize the palm subdomain of hepatitis C virus nonstructural protein 5B polymerase.  |  Ingravallo, P., et al. 2001. Virus Res. 75: 179-87. PMID: 11325472
5. Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A.  |  He, Y., et al. 2001. J Virol. 75: 5090-8. PMID: 11333890
6. The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.  |  Rho, J., et al. 2001. J Virol. 75: 8031-44. PMID: 11483748
7. Assessment of substrate specificity of hepatitis G virus NS3 protease by a genetic method.  |  Lee, YJ., et al. 2001. Biochem Biophys Res Commun. 286: 171-5. PMID: 11485324

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep C NS5b Antibody (1826) has 4 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep C NS5b Antibody (1826) Specifications

Alternate Product Name: Hep C NS5b

Product Clone Name: 1826

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Hep C NS5b

Epitope Species: Hepatitis C virus

Product Reactivity/Detection: NS5b genotypes 1a and 1b

Species Reactivity/Detection: Hepatitis C virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Hep C NS5b Antibody (1826): N/A