Hep C NS5a Antibody (1877): sc-65458
- Hep C NS5a Antibody (1877) is a mouse monoclonal IgG2a, cited in 4 publications, provided at 100 µg/ml
- raised against full length Hep C NS5a
- recommended for detection of NS5a genotypes 1a and 1b of Hep C origin by WB, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Hep C NS5a Antibody (1877). This work is in progress.
QUICK LINKS
SEE ALSO...
Hep C NS5a Antibody (1877) is a mouse monoclonal IgG2a antibody that detects Hep C NS5a protein of Hepatitis C by western blotting (WB), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Hep C NS5a is a crucial nonstructural protein that plays a significant role in the viral life cycle, particularly in the replication of the Hepatitis C virus. Hep C NS5a is located in the cytoplasm of infected hepatocytes, where Hep C NS5a interacts with various cellular factors to facilitate viral RNA replication and assembly. The importance of cytoplasmic localization lies in Hep C NS5a′s ability to evade the host′s immune response while promoting viral persistence. Additionally, Hep C NS5a undergoes post-translational modifications, including phosphorylation, which are critical for function and influence the efficiency of viral replication. The phosphorylation state of Hep C NS5a can affect the virus′s ability to replicate and may also impact the development of antiviral resistance, making Hep C NS5a a key target for therapeutic intervention. Anti-Hep C NS5a antibody (1877) is an invaluable tool for researchers studying the mechanisms of Hepatitis C infection and the development of potential treatments.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Hep C NS5a Antibody (1877) References:
- Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagation. | Lim, YS. and Hwang, SB. 2011. J Biol Chem. 286: 11290-8. PMID: 21297162
- Hepatitis C virus NS5A protein modulates IRF-7-mediated interferon-α signaling. | Chowdhury, JB., et al. 2014. J Interferon Cytokine Res. 34: 16-21. PMID: 23962002
- Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection. | Eyre, NS., et al. 2014. J Virol. 88: 3636-52. PMID: 24429364
- Serine phosphorylation of the hepatitis C virus NS5A protein controls the establishment of replication complexes. | Ross-Thriepland, D., et al. 2015. J Virol. 89: 3123-35. PMID: 25552726
- Hepatitis C virus NS5A protein interacts with lysine methyltransferase SET and MYND domain-containing 3 and induces activator protein 1 activation. | Chen, M., et al. 2016. Microbiol Immunol. 60: 407-17. PMID: 27080060
- Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1. | Smirnova, OA., et al. 2016. Oxid Med Cell Longev. 2016: 8341937. PMID: 27200149
- Hepatitis C Virus NS5A Protein Promotes the Lysosomal Degradation of Hepatocyte Nuclear Factor 1α via Chaperone-Mediated Autophagy. | Matsui, C., et al. 2018. J Virol. 92: PMID: 29695419
- Sequential Phosphorylation of the Hepatitis C Virus NS5A Protein Depends on NS3-Mediated Autocleavage between NS3 and NS4A. | Chiang, CH., et al. 2020. J Virol. 94: PMID: 32699091
- ISGylation of Hepatitis C Virus NS5A Protein Promotes Viral RNA Replication via Recruitment of Cyclophilin A. | Abe, T., et al. 2020. J Virol. 94: PMID: 32727878
- Quantifying the Evolutionary Constraints and Potential of Hepatitis C Virus NS5A Protein. | Dai, L., et al. 2021. mSystems. 6: PMID: 33850042
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hep C NS5a Antibody (1877) | sc-65458 | 100 µg/ml | $322.00 |