Hep C NS4b Antibody (2H1): sc-52416

Hep C NS4b Antibody (2H1) is a mouse monoclonal IgG2b antibody that detects Hep C NS4b protein of Hep C origin by western blotting (WB), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Hep C NS4b antibody (2H1) is available as the non-conjugated format. Hep C NS4b protein plays a crucial role in the viral life cycle, particularly in the assembly of the replication complex, which is essential for efficient replication of the Hepatitis C virus. Hep C NS4b protein interacts with other nonstructural proteins, such as NS3 and NS5A, to form a multiprotein complex that facilitates viral RNA synthesis. This interaction presents potential as a target for antiviral therapies, as disrupting the assembly or function of this complex could hinder viral replication and reduce viral load in infected individuals. NS4b′s hydrophobic nature suggests involvement in membrane association, which is critical for replication complex localization within the host cell. Using Hep C NS4b (2H1) antibody in research can provide valuable insights into Hepatitis C pathogenesis mechanisms and explore new therapeutic intervention avenues.

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Hep C NS4b Antibody (2H1) References:

1. Diagnosis in the difficult case.  |  Fairley, KF., et al. 1975. Kidney Int Suppl. 4: S12-9. PMID: 1104974
2. The roles of hepatitis C virus proteins in modulation of cellular functions: a novel action mechanism of the HCV core protein on gene regulation by nuclear hormone receptors.  |  Watashi, K. and Shimotohno, K. 2003. Cancer Sci. 94: 937-43. PMID: 14611668
3. Detection and quantitation of HCV core protein in single hepatocytes by means of laser capture microdissection and enzyme-linked immunosorbent assay.  |  Sansonno, D., et al. 2004. J Viral Hepat. 11: 27-32. PMID: 14738555
4. Nucleic acid binding properties and intermediates of HCV core protein multimerization in Pichia pastoris.  |  Acosta-Rivero, N., et al. 2004. Biochem Biophys Res Commun. 323: 926-31. PMID: 15381089
5. Morphological alteration and biological properties of hepatocytes not related to tumorigenesis following transfection with HCV core protein.  |  Gu, J., et al. 2005. J Viral Hepat. 12: 20-6. PMID: 15655044
6. Profiles of HCV core protein and viremia in chronic hepatitis C: possible protective role of core antigen in liver damage.  |  Carabaich, A., et al. 2005. J Med Virol. 76: 55-60. PMID: 15778969
7. HCV core protein augments cyclosporine immunosuppression.  |  Kimball, P., et al. 2005. Transplant Proc. 37: 652-3. PMID: 15848490
8. Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells.  |  Alisi, A., et al. 2005. J Cell Physiol. 205: 25-31. PMID: 15880455
9. Hepatitis C virus (HCV) core protein enhances the immunogenicity of a co-delivered DNA vaccine encoding HCV structural antigens in mice.  |  Alvarez-Lajonchere, L., et al. 2006. Biotechnol Appl Biochem. 44: 9-17. PMID: 16367740
10. Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3.  |  Umehara, T., et al. 2004. Nucleic Acids Symp Ser (Oxf). 195-6. PMID: 17150545

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep C NS4b Antibody (2H1) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep C NS4b Antibody (2H1) Specifications

Alternate Product Name: Hep C NS4b

Product Clone Name: 2H1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Hep C NS4b

Epitope Species: Hepatitis C virus

Product Reactivity/Detection: an epitope corresponding to amino acids 1710-1730 of NS4 region

Species Reactivity/Detection: Hep C

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Hep C NS4b Antibody (2H1): N/A