Hep C NS4a Antibody (4F5): sc-52415

Hep C NS4a Antibody (4F5) is a mouse monoclonal IgG1 antibody that detects Hep C NS4a protein by western blotting (WB) and immunofluorescence (IF). Anti-Hep C NS4a antibody (4F5) is available as a non-conjugated format. The Hepatitis C virus (HCV) is a significant global health concern, primarily due to its role in chronic liver disease and hepatocellular carcinoma. NS4a protein is crucial for the viral life cycle, interacting with other non-structural proteins to form a replication complex essential for viral RNA synthesis. NS4a associates with NS5a and NS5b, enhancing their activities and stability within the replication complex. This interaction facilitates efficient viral replication while playing a role in evading host immune response. Understanding NS4a function and interactions is important for developing targeted therapies against Hepatitis C, as disrupting these interactions could hinder viral replication and improve treatment outcomes.

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Hep C NS4a Antibody (4F5) References:

1. Diagnosis in the difficult case.  |  Fairley, KF., et al. 1975. Kidney Int Suppl. 4: S12-9. PMID: 1104974
2. The roles of hepatitis C virus proteins in modulation of cellular functions: a novel action mechanism of the HCV core protein on gene regulation by nuclear hormone receptors.  |  Watashi, K. and Shimotohno, K. 2003. Cancer Sci. 94: 937-43. PMID: 14611668
3. Detection and quantitation of HCV core protein in single hepatocytes by means of laser capture microdissection and enzyme-linked immunosorbent assay.  |  Sansonno, D., et al. 2004. J Viral Hepat. 11: 27-32. PMID: 14738555
4. Nucleic acid binding properties and intermediates of HCV core protein multimerization in Pichia pastoris.  |  Acosta-Rivero, N., et al. 2004. Biochem Biophys Res Commun. 323: 926-31. PMID: 15381089
5. Morphological alteration and biological properties of hepatocytes not related to tumorigenesis following transfection with HCV core protein.  |  Gu, J., et al. 2005. J Viral Hepat. 12: 20-6. PMID: 15655044
6. Profiles of HCV core protein and viremia in chronic hepatitis C: possible protective role of core antigen in liver damage.  |  Carabaich, A., et al. 2005. J Med Virol. 76: 55-60. PMID: 15778969
7. HCV core protein augments cyclosporine immunosuppression.  |  Kimball, P., et al. 2005. Transplant Proc. 37: 652-3. PMID: 15848490
8. Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells.  |  Alisi, A., et al. 2005. J Cell Physiol. 205: 25-31. PMID: 15880455
9. Hepatitis C virus (HCV) core protein enhances the immunogenicity of a co-delivered DNA vaccine encoding HCV structural antigens in mice.  |  Alvarez-Lajonchere, L., et al. 2006. Biotechnol Appl Biochem. 44: 9-17. PMID: 16367740
10. Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3.  |  Umehara, T., et al. 2004. Nucleic Acids Symp Ser (Oxf). 195-6. PMID: 17150545

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep C NS4a Antibody (4F5) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep C NS4a Antibody (4F5) Specifications

Alternate Product Name: Hep C NS4a

Product Clone Name: 4F5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 1700-1710

Epitope Target: NS4a region

Epitope Species: Hepatitis C

Product Reactivity/Detection: NS4a region

Species Reactivity/Detection: Hep C

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: Hep C

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Hep C NS4a Antibody (4F5): N/A