Hep C NS4 Antibody (1G7): sc-52414

Hep C NS4 Antibody (1G7) is a mouse monoclonal IgG2a antibody that detects the Hep C NS4 protein of Hep C origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Hep C NS4 (1G7) antibody is available in both non-conjugated and various conjugated forms, including fluorescein isothiocyanate (FITC), providing flexibility for different experimental needs. The Hepatitis C virus, a small, enveloped, single-stranded, positive-sense RNA virus from the Flaviviridae family, primarily targets hepatocytes in the liver for replication. This localization allows viral exploitation of liver cellular machinery, leading to production of approximately one trillion viral particles daily in infected individuals. Hep C NS4 plays a significant role in the viral life cycle by enhancing NS3 protein′s proteolytic activity through protein-protein interactions, essential for viral replication and proliferation. The high mutation rate of Hep C, attributed to RNA polymerase′s lack of proofreading, enables immune response evasion, resulting in chronic infections that can progress to liver cirrhosis and hepatocellular carcinoma. Understanding Hep C NS4 function and interactions is vital for developing targeted therapies and improving treatment outcomes for those affected by Hepatitis C.

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Hep C NS4 Antibody (1G7) References:

1. Diagnosis in the difficult case.  |  Fairley, KF., et al. 1975. Kidney Int Suppl. 4: S12-9. PMID: 1104974
2. The roles of hepatitis C virus proteins in modulation of cellular functions: a novel action mechanism of the HCV core protein on gene regulation by nuclear hormone receptors.  |  Watashi, K. and Shimotohno, K. 2003. Cancer Sci. 94: 937-43. PMID: 14611668
3. Detection and quantitation of HCV core protein in single hepatocytes by means of laser capture microdissection and enzyme-linked immunosorbent assay.  |  Sansonno, D., et al. 2004. J Viral Hepat. 11: 27-32. PMID: 14738555
4. Nucleic acid binding properties and intermediates of HCV core protein multimerization in Pichia pastoris.  |  Acosta-Rivero, N., et al. 2004. Biochem Biophys Res Commun. 323: 926-31. PMID: 15381089
5. Morphological alteration and biological properties of hepatocytes not related to tumorigenesis following transfection with HCV core protein.  |  Gu, J., et al. 2005. J Viral Hepat. 12: 20-6. PMID: 15655044
6. Profiles of HCV core protein and viremia in chronic hepatitis C: possible protective role of core antigen in liver damage.  |  Carabaich, A., et al. 2005. J Med Virol. 76: 55-60. PMID: 15778969
7. HCV core protein augments cyclosporine immunosuppression.  |  Kimball, P., et al. 2005. Transplant Proc. 37: 652-3. PMID: 15848490
8. Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells.  |  Alisi, A., et al. 2005. J Cell Physiol. 205: 25-31. PMID: 15880455
9. Hepatitis C virus (HCV) core protein enhances the immunogenicity of a co-delivered DNA vaccine encoding HCV structural antigens in mice.  |  Alvarez-Lajonchere, L., et al. 2006. Biotechnol Appl Biochem. 44: 9-17. PMID: 16367740
10. Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3.  |  Umehara, T., et al. 2004. Nucleic Acids Symp Ser (Oxf). 195-6. PMID: 17150545

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep C NS4 Antibody (1G7) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep C NS4 Antibody (1G7) Specifications

Alternate Product Name: Hep C NS4

Product Clone Name: 1G7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids: 1685-1863

Epitope Target: NS4 region

Epitope Species: Hepatitis C

Product Reactivity/Detection: NS4 region

Species Reactivity/Detection: Hep C

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: Hep C

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Hep C NS4 Antibody (1G7): FITC: Fluoroscein